Matrixyl
- Terminal modifications
- N-terminal palmitoyl
- Structural modifications
- not recorded
parent and analog
Matrixyl vs KTTKS (Pentapeptide-4)
The Matrixyl record describes N-palmitoylated KTTKS. The unmodified KTTKS peptide has a separate molecular identity.
Published: 2026-10-03Library record comparison: 2026-10-03
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Identity side by side
| Recorded field | Matrixyl | KTTKS (Pentapeptide-4) |
|---|---|---|
| Canonical name | Palmitoyl pentapeptide-4 | KTTKS |
| Aliases | Pal-KTTKS; Palmitoyl-KTTKS; Palmitoyl pentapeptide-3 | Pentapeptide-4; Collagen pentapeptide |
| Development codes | not recorded | not recorded |
| CAS | 214047-00-4 | 149128-48-3 |
| UNII | KK181SM5JG | not recorded |
| PubChem CID | 9897237 | 9959565 |
| Molecular formula | C39H75N7O10 | C23H45N7O9 |
| Molecular weight (Da) | 802.1 | 563.65 |
| Sequence length (residues) | not recorded | 5 |
| Terminal modifications | N-terminal palmitoyl | not recorded |
| Structural modifications | not recorded | not recorded |
Matrixyl: nomenclature notes
Matrixyl is a trade name for palmitoyl pentapeptide-4, the pentapeptide Lys-Thr-Thr-Lys-Ser (KTTKS) carrying an N-terminal palmitoyl group. The source review notes that KTTKS has become erroneously associated with the term pentapeptide in cosmetic marketing, and that the material has also been designated palmitoyl pentapeptide-3 under earlier INCI naming. Identity should be established against CAS 214047-00-4.
KTTKS (Pentapeptide-4): nomenclature notes
KTTKS is not Matrixyl. Matrixyl is the palmitoylated derivative, Pal-KTTKS, and N-palmitoylation adds C16H30O — 238.2297 Da — changing both the covalent structure and the physicochemical behaviour. 'Pentapeptide-4' alone does not distinguish them, which is why the sequence should always accompany the name.
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Recorded modification details
An aligned one-letter sequence is not recorded for this pair. The stored modification and sequence notes are shown below.
KTTKS (Pentapeptide-4)
- Terminal modifications
- not recorded
- Structural modifications
- not recorded
- Stored three-letter notation
- Lys · Thr · Thr · Lys · Ser · OH
- Sequence notes
- Five residues, all L, free at both termini. No palmitoylation, no ring, no metal.
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Recorded mechanisms
These lists show the links recorded in each monograph. An unlisted link does not establish its absence from the molecule’s biology.
Shared recorded links
not recorded
Recorded only for Matrixyl
not recorded
Recorded only for KTTKS (Pentapeptide-4)
not recorded
04
Recorded compound classes
Shared recorded links
Recorded only for Matrixyl
not recorded
Recorded only for KTTKS (Pentapeptide-4)
not recorded
05
References for the relationship
- Development of a LC-MS/MS method to monitor palmitoyl peptides content in anti-wrinkle cosmetics.
Chirita RI, Chaimbault P, Archambault JC, Robert I, Elfakir C
Analytica chimica acta · 2009-03-20 · Journal Article
current - A pentapeptide from type I procollagen promotes extracellular matrix production.
Katayama K, Armendariz-Borunda J, Raghow R, Kang AH, Seyer JM
The Journal of biological chemistry · 1993-05-15 · Journal Article
current
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