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Oxyntomodulin vs Glucagon

The complete glucagon residue sequence forms the N-terminal portion of oxyntomodulin. Oxyntomodulin has an additional eight-residue C-terminal extension.

Published: 2026-10-03Library record comparison: 2026-10-03

Identity side by side

Recorded molecular identities of Oxyntomodulin and Glucagon
Recorded field	Oxyntomodulin	Glucagon
Canonical name	Oxyntomodulin	Glucagon
Aliases	OXM; Glucagon-37	Glucagon(1-29)
Development codes	not recorded	not recorded
CAS	not recorded	16941-32-5
UNII	LV7ELH7V16	76LA80IG2G
PubChem CID	not recorded	not recorded
Molecular formula	C192H295N61O60S	C153H225N43O49S
Molecular weight (Da)	4449.9	3482.8
Sequence length (residues)	37	29
Terminal modifications	not recorded	not recorded
Structural modifications	not recorded	not recorded

Oxyntomodulin: nomenclature notes

Oxyntomodulin is ONE peptide, not a mixture of GLP-1 and glucagon. It is also not glicentin, which is a larger processing product that contains the oxyntomodulin region — and both carry the same KRNRNNIA C-terminus, so recognising that region does not distinguish them. Separately, 'oxyntomodulin-like' is a description of GLP-1R/GCGR pharmacology and does not establish oxyntomodulin-derived chemistry; a compound can have that pharmacology from a different scaffold entirely. FINALLY, AND THE REASON NO pubChemCid IS RECORDED: PubChem CID 16144019 displays the C-terminus as KRNKNNIA, with lysine where the reviewed human sequence has arginine at oxyntomodulin position 33. Arginine carries two more nitrogens than lysine, which is why that record shows N59 against this entry's N61. Its formula and mass describe a variant and must not be applied to the human sequence.

Glucagon: nomenclature notes

Mature glucagon, not proglucagon and not a generic glucagon-family peptide. Glucagon, GLP-1 and oxyntomodulin are related through processing of a shared precursor but are not aliases. Note particularly that this entire 29-residue sequence is contained within oxyntomodulin, which extends it by eight residues — that containment is exactly why the two are analytically difficult to separate.

Residue sequence comparison

Positions are numbered from each stored sequence’s first residue. Highlighted cells differ or extend beyond the other chain; a dash indicates no aligned residue. One-letter notation does not encode terminal groups or stereochemistry. Read the recorded notes below.

Aligned one-letter residue sequences
Oxyntomodulin	1H	2S	3Q	4G	5T	6F	7T	8S	9D	10Y	11S	12K	13Y	14L	15D	16S	17R	18R	19A	20Q	21D	22F	23V	24Q	25W	26L	27M	28N	29T	30K	31R	32N	33R	34N	35N	36I	37A
Glucagon	1H	2S	3Q	4G	5T	6F	7T	8S	9D	10Y	11S	12K	13Y	14L	15D	16S	17R	18R	19A	20Q	21D	22F	23V	24Q	25W	26L	27M	28N	29T	·—	·—	·—	·—	·—	·—	·—	·—

Differences in text

Oxyntomodulin: residue 30 = K; Glucagon: no aligned residue.
Oxyntomodulin: residue 31 = R; Glucagon: no aligned residue.
Oxyntomodulin: residue 32 = N; Glucagon: no aligned residue.
Oxyntomodulin: residue 33 = R; Glucagon: no aligned residue.
Oxyntomodulin: residue 34 = N; Glucagon: no aligned residue.
Oxyntomodulin: residue 35 = N; Glucagon: no aligned residue.
Oxyntomodulin: residue 36 = I; Glucagon: no aligned residue.
Oxyntomodulin: residue 37 = A; Glucagon: no aligned residue.

Oxyntomodulin

Terminal modifications: not recorded
Structural modifications: not recorded
Sequence notes: Thirty-seven residues, free at both termini. The first twenty-nine are the complete glucagon sequence; the C-terminal extension is KRNRNNIA. Species and the extension must both be explicit.

Glucagon

Terminal modifications: not recorded
Structural modifications: not recorded
Sequence notes: Twenty-nine residues, free at both termini, no modifications.