Compound class
Incretin and glucagon receptor ligands
Endogenous hormones acting at the GLP-1, GIP and glucagon receptors, held together without any claim of common chemical ancestry. It exists so native hormones are not filed in a class of analogs of themselves.
01
Neutral class definition
Endogenous hormones acting at the GLP-1, GIP and glucagon receptors, held together without any claim of common chemical ancestry. It exists so native hormones are not filed in a class of analogs of themselves.
02
Related compounds
Compound
Glucagon
Glucagon is the endogenous 29-residue pancreatic hormone and the native ligand of the glucagon receptor. Horváth et al. (PMID 37528104) place glucagon among the gastrointestinal peptides of the glucagon family.
Glucagon(1-29)
Compound
GLP-1(7-36) amide
GLP-1(7-36) amide is an endogenous processing form of glucagon-like peptide-1 and the native ligand against which the GLP-1 receptor agonists in this library are compared. Deacon et al. (PMID 7556682) isolated this form from human colon and conclude that it is a product of proglucagon processing. Horváth et al. (PMID 37528104) place GLP-1 among the gastrointestinal peptides of the glucagon family.
GLP-1(7-36)amide · GLP-1 7-36 amide
Compound
GLP-1(7-37)
GLP-1(7-37) is an endogenous processing form of glucagon-like peptide-1 retaining a C-terminal glycine, and the structural reference for several acylated GLP-1 analogs. Mojsov et al. (PMID 3543057) describe the glucagon-like peptides as liberated from proglucagon in both the pancreas and the intestine. Horváth et al. (PMID 37528104) place GLP-1 among the gastrointestinal peptides of the glucagon family.
GLP-1 7-37 · GLP-I(7-37) · Insulinotropin
Compound
GIP(1-42)
GIP is a 42-residue endogenous incretin hormone and the native ligand of the GIP receptor. Horváth et al. (PMID 37528104) place GIP among the gastrointestinal peptides of the glucagon family.
GIP · Gastric inhibitory polypeptide · Glucose-dependent insulinotropic peptide
Compound
Oxyntomodulin
Oxyntomodulin is an endogenous proglucagon-derived peptide containing the complete glucagon sequence plus an eight-residue C-terminal extension, with reported activity at both the GLP-1 and glucagon receptors. A review by Bataille and Dalle (PMID 25115338) describes oxyntomodulin as a member of the glucagon family; that is a review-level family attribution.
OXM · Glucagon-37
03
Related molecular mechanisms
receptor
Glucagon receptor
GCGR is a class B G-protein-coupled receptor. Retatrutide's LY3437943 discovery record characterizes a molecular agonist relationship at GCGR alongside GIPR and GLP-1R.
receptor
Glucagon-like peptide-1 receptor
GLP-1R is a class B G-protein-coupled receptor. The cited structural and pharmacology records characterize semaglutide and retatrutide as peptide agonists at this receptor.
receptor
Glucose-dependent insulinotropic polypeptide receptor
GIPR is a class B G-protein-coupled receptor. The cited discovery and trial records identify it as one of the three receptor relationships declared for retatrutide.
04
Relevant glossary terms
05
Verified bibliography
Reference 1
Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum.Mentlein R, Gallwitz B, Schmidt WE
European journal of biochemistry · 1993-06-15 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Mentlein R et al. 1993 | Study models reported: in vitro · from the abstract |
06
Related Purely Peptides research articles
No existing Research Article is mapped to this class seed record.
07