Molecular mechanism
Angiotensin receptors
The angiotensin receptor family includes the AT1 and AT2 G-protein-coupled receptors. Direct binding experiments and structures of receptor–peptide complexes establish interaction with the Ile5 angiotensin II parent. Receptor subtype, organism and engineered receptor construct are distinguished in the cited studies.
See this target on the receptor map
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Neutral molecular overview
The angiotensin receptor family includes the AT1 and AT2 G-protein-coupled receptors. Direct binding experiments and structures of receptor–peptide complexes establish interaction with the Ile5 angiotensin II parent. Receptor subtype, organism and engineered receptor construct are distinguished in the cited studies.
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Target identifiers
No target identifier beyond the verified name and aliases is listed for this mechanism.
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Related compounds
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Related mechanisms
No related mechanism is declared in this seed record.
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Verified bibliography
Reference 1
Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR.Wingler LM, Skiba MA, McMahon C, Staus DP, Kleinhenz ALW, Suomivuori CM, Latorraca NR, Dror RO, Lefkowitz RJ, Kruse AC
Science (New York, N.Y.) · 2020-02-21 · Journal Article
currentReference 2
The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone.Asada H, Inoue A, Ngako Kadji FM, Hirata K, Shiimura Y, Im D, Shimamura T, Nomura N, Iwanari H, Hamakubo T, Kusano-Arai O, Hisano H, Uemura T, Suno C, Aoki J, Iwata S
Structure (London, England : 1993) · 2019-12-30 · Journal Article
currentReference 3
Angiotensin II type 1 and type 2 receptors bind angiotensin II through different types of epitope recognition.Miura S, Karnik SS
Journal of hypertension · 1999-03 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Wingler LM et al. 2020 | Study models reported: in vitro · from the abstract |
| Asada H et al. 2019 | Study models reported: in vitro · from the abstract |
| Miura S et al. 1999 | Study models reported: in vitro · from the abstract |
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Related glossary terms
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Related Purely Peptides research articles
No existing Research Article is mapped to this mechanism seed record.