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Molecular mechanism

Bradykinin B2 receptor

The human bradykinin B2 receptor is a G protein-coupled receptor. The cited studies characterize bradykinin-bound receptor structures and icatibant recognition in identified receptor preparations.

Type: receptorPublished: 2026-10-22Literature/identifier verification: 2026-10-22

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01

Neutral molecular overview

The human bradykinin B2 receptor is a G protein-coupled receptor. The cited studies characterize bradykinin-bound receptor structures and icatibant recognition in identified receptor preparations.

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Target identifiers

No target identifier beyond the verified name and aliases is listed for this mechanism.

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Related compounds

Compound

Bradykinin

Bradykinin is a linear nonapeptide composed of standard amino-acid residues, with free N and C termini.

Compound

Icatibant

Icatibant is a synthetic linear decapeptide containing D-configured and nonproteinogenic amino-acid units. This record describes its counterion-free parent peptide.

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Related mechanisms

No related mechanism is declared in this seed record.

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Verified bibliography

  1. Reference 1

    Molecular basis for kinin selectivity and activation of the human bradykinin receptors.

    Yin YL, Ye C, Zhou F, Wang J, Yang D, Yin W, Wang MW, Xu HE, Jiang Y

    Nature structural & molecular biology · 2021-09-09 · Journal Article

    current
    PMID 34518695DOI 10.1038/s41594-021-00645-yBradykininBradykinin B2 receptor

  2. Reference 2

    Cryo-EM structures of human bradykinin receptor-G(q) proteins complexes.

    Shen J, Zhang D, Fu Y, Chen A, Yang X, Zhang H

    Nature communications · 2022-02-07 · Journal Article

    current
    PMID 35132089PMC8821558DOI 10.1038/s41467-022-28399-1BradykininBradykinin B2 receptor

  3. Reference 3

    Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies.

    Hock FJ, Wirth K, Albus U, Linz W, Gerhards HJ, Wiemer G, Henke S, Breipohl G, König W, Knolle J

    British journal of pharmacology · 1991-03 · Journal Article

    current
    PMID 1364851PMC1917958DOI 10.1111/j.1476-5381.1991.tb12248.xIcatibantBradykinin B2 receptor

  4. Reference 4

    In Vitro Pharmacological Profile of a New Small Molecule Bradykinin B(2) Receptor Antagonist.

    Lesage A, Gibson C, Marceau F, Ambrosi HD, Saupe J, Katzer W, Loenders B, Charest-Morin X, Knolle J

    Frontiers in pharmacology · 2020-06-19 · Journal Article

    current
    PMID 32636746PMC7316994DOI 10.3389/fphar.2020.00916IcatibantBradykinin B2 receptor

Study models of these references

What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.

ReferenceStudy models
Yin YL et al. 2021Study models reported: in vitro · from the abstract
Shen J et al. 2022Study models reported: in vitro · from the abstract
Hock FJ et al. 1991Study models reported: in vitro · from the abstract
Lesage A et al. 2020Study models reported: in vitro · from the abstract

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Related glossary terms

AgonistLigandG-protein-coupled receptor

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Related Purely Peptides research articles

No existing Research Article is mapped to this mechanism seed record.