Compound monograph
Icatibant
Icatibant is a synthetic linear decapeptide containing D-configured and nonproteinogenic amino-acid units. This record describes its counterion-free parent peptide.
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Identity & nomenclature
Icatibant is a synthetic linear decapeptide containing D-configured and nonproteinogenic amino-acid units. This record describes its counterion-free parent peptide.
Icatibantum is the WHO Latin name. HOE 140 is admitted with a form boundary and does not fix acetate stoichiometry. Acetate identifiers are excluded. An IUPHAR DL/underspecified encoding conflicts with the fully assigned WHO/FDA/EMA parent and is not imported.
Declared aliases and development codes: Icatibantum, HOE 140.
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Molecular properties
| Molecular formula | C59H89N19O13S |
|---|---|
| Molecular mass | 1304.541 Da |
| CAS Registry Number | 130308-48-4 |
| PubChem CID | 6918173 |
| UNII | 7PG89G35Q7 |
| Three-letter sequence | D-Arg–Arg–Pro–Hyp–Gly–Thi–Ser–D-Tic–Oic–Arg |
| Terminal groups | Free N-terminus; Free C-terminal carboxyl |
The ten tokens are ordered from D-Arg1, which is D-arginine (R). Arg2, Pro3, Ser7 and Arg10 are L; Gly5 is achiral. Hyp4 is (2S,4R)-4-hydroxyproline. Thi6 is (S)-3-(thiophen-2-yl)alanine, the 2-thienyl isomer. D-Tic8 is the (3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid unit. Oic9 is the (2S,3aS,7aS)-octahydroindole-2-carboxylic acid unit. Intrinsic unit rings are not inter-residue closures. No standard one-letter string can encode these units faithfully.
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Structural characteristics
The ten tokens are ordered from D-Arg1, which is D-arginine (R). Arg2, Pro3, Ser7 and Arg10 are L; Gly5 is achiral. Hyp4 is (2S,4R)-4-hydroxyproline. Thi6 is (S)-3-(thiophen-2-yl)alanine, the 2-thienyl isomer. D-Tic8 is the (3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid unit. Oic9 is the (2S,3aS,7aS)-octahydroindole-2-carboxylic acid unit. Intrinsic unit rings are not inter-residue closures. No standard one-letter string can encode these units faithfully.
- D configuration at residues 1 and 8
- Residue-4 (2S,4R)-4-hydroxyproline
- Residue-6 (S)-3-(thiophen-2-yl)alanine
- Residue-8 (3R)-tetrahydroisoquinoline-3-carboxylic acid unit
- Residue-9 (2S,3aS,7aS)-octahydroindole-2-carboxylic acid unit
Terminal features: Free N-terminus, Free C-terminal carboxyl.
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Molecular targets & mechanisms
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Analytical considerations
The molecular formula describes the parent; the average mass is calculated using CIAAW 2024 abridged atomic weights. FDA prints 1304.55 (-0.009 Da, -6.899 ppm); EMA prints 1304.52 (+0.021 Da, +16.098 ppm). Both are non-defining published figures with unestablished precise conventions. They are not averaged. Mass alone cannot distinguish the N-terminal epimer.
What the studies reported
No verified findings are published for this record under Content Policy v1.
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Verified bibliography
Cited studies by type
The 2 papers this record cites, counted by the kind of work each reports. A count is the size of this record's selection, not of the research that exists, and says nothing about results, safety, effectiveness or approval.
A paper can report more than one kind of work. Each count opens those papers in the bibliography. Compare every record on the Evidence Map.
Reference 1
Halide-Mediated Electrochemical Peptide Synthesis Applicable to Highly Sterically Hindered Amino Acids.Shinjo-Nagahara S, Hiratsuka G, Okada Y, Kitano Y, Chiba K
Organic letters · 2026-02-05 · Journal Article
currentReference 2
The identification and chromatographic separation of a new highly analogous impurity of the active pharmaceutical ingredient icatibant.Lajin B, Steiner O, Fasshold L, Zangger K, Goessler W
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2019-03-06 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Shinjo-Nagahara S et al. 2026 | Chemical, structural or analytical study; no biological model reported |
| Lajin B et al. 2019 | Chemical, structural or analytical study; no biological model reported |
Record history
Published 2026-10-21.
No changes to this record's content have been recorded since publication.
Each entry names the parts of this record that changed on that date. Changes to links between records and to catalogue links are not listed. This history covers the tracked record fields; study findings are not listed here.
Cite this record: Purely Peptides Research Library. Icatibant. Published 2026-10-21. https://purelypeptides.org/research/compounds/icatibant/
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Methodology & citation verification
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