Molecular mechanism

Cholecystokinin 1 receptor

The cholecystokinin 1 receptor is a class A G-protein-coupled receptor. Independent structural studies identify sulfated CCK-8 bound to this receptor.

Type: receptorPublished: 2026-10-22Literature/identifier verification: 2026-10-22

See this target on the receptor map

CCK1RCCK-A receptorCCKAR

Neutral molecular overview

The cholecystokinin 1 receptor is a class A G-protein-coupled receptor. Independent structural studies identify sulfated CCK-8 bound to this receptor.

Target identifiers

No target identifier beyond the verified name and aliases is listed for this mechanism.

Related compounds

Compound

CCK-8 (sulfated)

Sincalide is a linear eight-residue peptide with Tyr2 O-sulfation, a free N terminus and a C-terminal phenylalanine amide.

Related mechanisms

No related mechanism is declared in this seed record.

Verified bibliography

Reference 1
Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor.
Liu Q, Yang D, Zhuang Y, Croll TI, Cai X, Dai A, He X, Duan J, Yin W, Ye C, Zhou F, Wu B, Zhao Q, Xu HE, Wang MW, Jiang Y
Nature chemical biology · 2021-09-23 · Journal Article
current
PMID 34556862 PMC8604728 DOI 10.1038/s41589-021-00841-3 CCK-8 (sulfated)CCK1R
Reference 2
Structural insights into human brain-gut peptide cholecystokinin receptors.
Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM
Cell discovery · 2022-06-07 · Journal Article
current
PMID 35672283 PMC9174195 DOI 10.1038/s41421-022-00420-3 CCK-8 (sulfated)CCK1R

Study models of these references

What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.

Reference	Study models
Liu Q et al. 2021	Study models reported: in vitro · from the abstract
Ding Y et al. 2022	Study models reported: in vitro · from the abstract

Related glossary terms

Agonist Ligand G-protein-coupled receptor