Compound monograph
CCK-8 (sulfated)
Sincalide is a linear eight-residue peptide with Tyr2 O-sulfation, a free N terminus and a C-terminal phenylalanine amide.
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Identity & nomenclature
Sincalide is a linear eight-residue peptide with Tyr2 O-sulfation, a free N terminus and a C-terminal phenylalanine amide.
The CCK-8 designation requires a sulfation qualifier. Sincalide is the issued name linked by GSRS to WHO Proposed INN List 32. Unqualified short names and unsupported development codes are withheld.
Canonical name: Sincalide.
Declared aliases and development codes: Sulfated cholecystokinin octapeptide, O-sulfated CCK-8.
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Molecular properties
| Molecular formula | C49H62N10O16S3 |
|---|---|
| Molecular mass | 1143.269 Da |
| CAS Registry Number | 25126-32-3 |
| PubChem CID | 9833444 |
| UNII | M03GIQ7Z6P |
| Three-letter sequence | Asp–Tyr(SO3H)–Met–Gly–Trp–Met–Asp–Phe |
| Terminal groups | Free N-terminus; C-terminal amide |
Positions count the eight-residue chain from Asp1. Tyr(SO3H) is L-tyrosine with a phenolic O-sulfate ester at position 2; it is one residue. All chiral residues are L and Gly4 is achiral. The sulfate is covalent; it is neither a counterion nor an inter-residue ring. A one-letter string would omit its identity.
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Structural characteristics
Positions count the eight-residue chain from Asp1. Tyr(SO3H) is L-tyrosine with a phenolic O-sulfate ester at position 2; it is one residue. All chiral residues are L and Gly4 is achiral. The sulfate is covalent; it is neither a counterion nor an inter-residue ring. A one-letter string would omit its identity.
- Residue-2 phenolic O-sulfation
Terminal features: Free N-terminus, C-terminal amide.
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Molecular targets & mechanisms
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Analytical considerations
The molecular formula describes the parent; the average mass is calculated using CIAAW 2024 abridged atomic weights. PubChem displays 1143.3 Da: -0.031 Da (-27.1145 ppm), consistent with one-decimal rounding. GSRS reports 1143.2742 (-0.0052 Da, -4.54834 ppm); its precise mass convention is unestablished. The FDA description prints 1143.27 (-0.001 Da, -0.874684 ppm), also under an unestablished convention.
What the studies reported
No verified findings are published for this record under Content Policy v1.
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Verified bibliography
Cited studies by type
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Reference 1
Enzymatic synthesis of cholecystokinin-octapeptide.Sakina K, Kawazura K, Morihara K, Yajima H
Chemical & pharmaceutical bulletin · 1988-10 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Sakina K et al. 1988 | Chemical, structural or analytical study; no biological model reported |
Record history
Published 2026-10-21.
- : Analytical notes
Each entry names the parts of this record that changed on that date. Changes to links between records and to catalogue links are not listed. This history covers the tracked record fields; study findings are not listed here.
Cite this record: Purely Peptides Research Library. CCK-8 (sulfated). Published 2026-10-21; updated 2026-10-21. https://purelypeptides.org/research/compounds/cck-8/
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Methodology & citation verification
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