Molecular mechanism
Galanin receptors
The galanin receptor family comprises three G protein-coupled receptors. GALR1 and GALR3 signal through Gi/o, while GALR2 signals mainly through Gq/11. Spexin activates GALR2 and GALR3 but not GALR1 in the reported ligand panel. Structural studies compared galanin-bound GALR1-Go and GALR2-Gq with spexin-bound GALR2-Gq, providing evidence for ligand recognition and subtype-dependent coupling.
See this target on the receptor map
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Neutral molecular overview
The galanin receptor family comprises three G protein-coupled receptors. GALR1 and GALR3 signal through Gi/o, while GALR2 signals mainly through Gq/11. Spexin activates GALR2 and GALR3 but not GALR1 in the reported ligand panel. Structural studies compared galanin-bound GALR1-Go and GALR2-Gq with spexin-bound GALR2-Gq, providing evidence for ligand recognition and subtype-dependent coupling.
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Target identifiers
- Gene symbols
- GALR1, GALR2, GALR3
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Related compounds
Compound
Galanin (human 1-30)
Galanin is a thirty-residue human neuropeptide acting through the galanin receptor family, and the reference ligand against which spexin's receptor selectivity is measured.
Compound
Spexin
Spexin is an endogenous fourteen-residue amidated neuropeptide identified by computational screening of the human proteome, and a ligand of galanin receptors 2 and 3.
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Related mechanisms
No related mechanism is declared in this seed record.
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Verified bibliography
Reference 1
Structural insights into galanin receptor signaling.Jiang W, Zheng S
Proceedings of the National Academy of Sciences of the United States of America · 2022-05-20 · Journal Article
currentReference 2
Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.Kim DK, Yun S, Son GH, Hwang JI, Park CR, Kim JI, Kim K, Vaudry H, Seong JY
Endocrinology · 2014-02-11 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Jiang W et al. 2022 | Study models reported: in vitro · from the abstract |
| Kim DK et al. 2014 | Study models reported: in vitro · from the abstract |
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Related glossary terms
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Related Purely Peptides research articles
No existing Research Article is mapped to this mechanism seed record.