Compound monograph
Kisspeptin-14
Kisspeptin-14 is a KISS1-derived peptide isolated from human placental extracts, containing kisspeptin-10 as its C-terminal decapeptide, and an agonist at the kisspeptin receptor.
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Identity & nomenclature
Kisspeptin-14 is a KISS1-derived peptide isolated from human placental extracts, containing kisspeptin-10 as its C-terminal decapeptide, and an agonist at the kisspeptin receptor.
A fourteen-residue kisspeptin was isolated from human placenta alongside the 54- and 13-residue forms. KP-14 contains the kisspeptin-10 sequence at its C terminus. Removing its initial aspartate gives the 13-residue sequence; removing DLPN gives the 10-residue sequence. These are different molecular forms even where receptor responses are similar.
Declared aliases and development codes: KP-14, Metastin(41-54).
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Molecular properties
| Molecular formula | C82H112N22O21 |
|---|---|
| Molecular mass | 1741.9 Da |
| CAS Registry Number | 374675-19-1 |
| PubChem CID | 171916517 |
| One-letter sequence | DLPNYNWNSFGLRF |
| Terminal groups | Free N-terminus; C-terminal amide |
Fourteen residues with a C-terminal amide, free N-terminus, no cyclization or nonstandard residue. The final ten residues are the entire kisspeptin-10 sequence; the distinguishing part is the N-terminal DLPN.
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Structural characteristics
The 54-, 14- and 13-residue kisspeptins were isolated from human placenta together, share a common C-terminal RF-amide, and bound rat and human GPR54 with low nanomolar affinity. A cryo-EM structure of the receptor exists but was determined with kisspeptin-10; the shared C-terminal pharmacophore makes it useful context for this entry rather than evidence about how KP-14's four additional N-terminal residues behave when bound. Whether KP-14 is produced in vivo from a longer form, and by which enzyme, is not established, and shared sequence is not by itself evidence of a serial processing pathway.
Terminal features: Free N-terminus, C-terminal amide.
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Molecular targets & mechanisms
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Analytical considerations
Sequence coverage must span the DLPN extension, not only the shared ten-residue tail, or the result cannot distinguish KP-14 from KP-13 or KP-10. Asparagine deamidation and loss of the terminal amide each produce a change near 0.98 Da, so intact mass can detect that something happened but not where. A receptor response is useful functional evidence and identifies no particular chain length.
Disagreements and mix-ups
Points where sources disagree about this compound's identity, or where a name or form is easily confused with another, as noted in this record. The discrepancy register quotes the passage for each one.
Often mixed up · Name or substance
Kisspeptin-14 vs the 13- and 10-residue kisspeptins
What the studies reported
Each finding describes one cited study in its stated model. These observations are specific to that study and do not establish effects in other settings.
Cell and tissue studies
Human placental peptide isolation and identification
Using human placental peptide isolation and identification, the study identified kisspeptins including a 14-residue peptide with a common RF-amide C terminus.
Reference [1]Chinese hamster ovary K1 cells expressing rat or human GPR54
Using Chinese hamster ovary K1 cells expressing rat or human GPR54, the study reported low-nanomolar binding affinities for the isolated kisspeptins, which included the 14-residue peptide.
Reference [1]Chinese hamster ovary K1 cells expressing rat or human GPR54
Using Chinese hamster ovary K1 cells expressing rat or human GPR54, the study reported PIP2 hydrolysis, calcium mobilization, arachidonic acid release and ERK1/2 and p38 MAP kinase phosphorylation with the isolated kisspeptins, which included the 14-residue peptide.
Reference [1]Chinese hamster ovary K1 cells expressing rat or human GPR54
Using Chinese hamster ovary K1 cells expressing rat or human GPR54, the study observed inhibited proliferation with the isolated kisspeptins, which included the 14-residue peptide.
Reference [1]
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Verified bibliography
Cited studies by type
The 3 papers this record cites, counted by the kind of work each reports. A count is the size of this record's selection, not of the research that exists, and says nothing about results, safety, effectiveness or approval.
A paper can report more than one kind of work. Each count opens those papers in the bibliography. Compare every record on the Evidence Map.
Reference 1
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brézillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M
The Journal of biological chemistry · 2001-07-16 · Journal Article
currentReference 2
Structural basis for hormone recognition and distinctive Gq protein coupling by the kisspeptin receptor.Shen S, Wang D, Liu H, He X, Cao Y, Chen J, Li S, Cheng X, Xu HE, Duan J
Cell reports · 2024-06-26 · Journal Article
currentReference 3
Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.Kim DK, Yun S, Son GH, Hwang JI, Park CR, Kim JI, Kim K, Vaudry H, Seong JY
Endocrinology · 2014-02-11 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Kotani M et al. 2001 | Study models reported: in vitro; animal (rat) · from the abstract |
| Shen S et al. 2024 | Study models reported: in vitro · from the abstract |
| Kim DK et al. 2014 | Study models reported: in vitro · from the abstract |
Compare
Record history
Published 2026-09-19.
- : Sequence and structure
Each entry names the parts of this record that changed on that date. Changes to links between records and to catalogue links are not listed. This history covers the tracked record fields; study findings are not listed here.
Cite this record: Purely Peptides Research Library. Kisspeptin-14. Published 2026-09-19; updated 2026-10-14. https://purelypeptides.org/research/compounds/kisspeptin-14/
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Methodology & citation verification
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