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Research Catalog

Molecular mechanism

Secretin receptor

The secretin receptor, encoded by SCTR, is a class B G-protein-coupled receptor. Independent structural studies characterize human secretin bound to this receptor.

Type: receptorPublished: 2026-10-22Literature/identifier verification: 2026-10-22

See this target on the receptor map

01

Neutral molecular overview

The secretin receptor, encoded by SCTR, is a class B G-protein-coupled receptor. Independent structural studies characterize human secretin bound to this receptor.

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Target identifiers

Gene symbols
SCTR

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Related compounds

Compound

Human secretin

Human secretin is a linear 27-residue peptide with a free N-terminal histidine and a C-terminal valine amide.

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Related mechanisms

No related mechanism is declared in this seed record.

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Verified bibliography

  1. Reference 1

    Structure and dynamics of the active Gs-coupled human secretin receptor.

    Dong M, Deganutti G, Piper SJ, Liang YL, Khoshouei M, Belousoff MJ, Harikumar KG, Reynolds CA, Glukhova A, Furness SGB, Christopoulos A, Danev R, Wootten D, Sexton PM, Miller LJ

    Nature communications · 2020-08-18 · Journal Article

    current
    PMID 32811827PMC7435274DOI 10.1038/s41467-020-17791-4Human secretinSecretin receptor

  2. Reference 2

    Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein.

    Fukuhara S, Kobayashi K, Kusakizako T, Iida W, Kato M, Shihoya W, Nureki O

    Biochemical and biophysical research communications · 2020-09-30 · Journal Article

    current
    PMID 33008599DOI 10.1016/j.bbrc.2020.08.042Human secretinSecretin receptor

  3. Reference 3

    Rational development of a high-affinity secretin receptor antagonist.

    Dong M, Harikumar KG, Raval SR, Milburn JE, Clark C, Alcala-Torano R, Mobarec JC, Reynolds CA, Ghirlanda G, Christopoulos A, Wootten D, Sexton PM, Miller LJ

    Biochemical pharmacology · 2020-03-23 · Journal Article

    current
    PMID 32217097PMC7299832DOI 10.1016/j.bcp.2020.113929Human secretinSecretin receptor

Study models of these references

What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.

ReferenceStudy models
Dong M et al. 2020Study models reported: in vitro · from the abstract
Fukuhara S et al. 2020Study models reported: in vitro · from the abstract
Dong M et al. 2020Study models reported: in vitro · from the abstract

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Related glossary terms

AgonistLigandG-protein-coupled receptor

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Related Purely Peptides research articles

No existing Research Article is mapped to this mechanism seed record.