Compound monograph

Human secretin

Human secretin is a linear 27-residue peptide with a free N-terminal histidine and a C-terminal valine amide.

Published: 2026-10-21Literature/identifier verification: 2026-10-21

Identity & nomenclature

Human secretin is a linear 27-residue peptide with a free N-terminal histidine and a C-terminal valine amide.

The name is species-qualified and identifies the mature human parent separately from precursor and salt forms. PubChem CID is withheld because competing human-parent assignments remain unresolved; the generic-name registry encoding is excluded.

Canonical name: Secretin human.

Molecular properties

Molecular formula	C130H220N44O40
Molecular mass	3039.458 Da
CAS Registry Number	108153-74-8
UNII	A0426J905J
One-letter sequence	HSDGTFTSELSRLREGARLQRLLQGLV
Three-letter sequence	His–Ser–Asp–Gly–Thr–Phe–Thr–Ser–Glu–Leu–Ser–Arg–Leu–Arg–Glu–Gly–Ala–Arg–Leu–Gln–Arg–Leu–Leu–Gln–Gly–Leu–Val
Terminal groups	Free N-terminus; C-terminal amide

Positions count the mature chain from 1. All chiral amino-acid residues are L; glycine is achiral. Terminal groups are recorded separately.

Structural characteristics

The chain contains standard L-amino-acid residues and no inter-residue covalent closure.

Terminal features: Free N-terminus, C-terminal amide.

Molecular targets & mechanisms

Analytical considerations

The molecular formula describes the parent; the average mass is calculated using CIAAW 2024 abridged atomic weights. The derived formula matches the WHO entry and matching PubChem structures. DailyMed prints C130H220N44O39, whose CIAAW average is 3023.459 Da, 15.999 Da below the derived value; its printed 3039.44 differs by +0.018 Da (+5.922 ppm) under an unestablished convention. GSRS gives the non-defining estimate C130H222N44O41, differing by H2O, and sequence-calculated 3038.0 Da: +1.458 Da (+479.921 ppm). PubChem reports 3039.4 Da: +0.058 Da (+19.083 ppm). These divergent values are non-defining.

What the studies reported

No verified findings are published for this record under Content Policy v1.

Verified bibliography

Cited studies by type

The 2 papers this record cites, counted by the kind of work each reports. A count is the size of this record's selection, not of the research that exists, and says nothing about results, safety, effectiveness or approval.

A paper can report more than one kind of work. Each count opens those papers in the bibliography. Compare every record on the Evidence Map.

Reference 1
Rational development of a high-affinity secretin receptor antagonist.
Dong M, Harikumar KG, Raval SR, Milburn JE, Clark C, Alcala-Torano R, Mobarec JC, Reynolds CA, Ghirlanda G, Christopoulos A, Wootten D, Sexton PM, Miller LJ
Biochemical pharmacology · 2020-03-23 · Journal Article
current
PMID 32217097 PMC7299832 DOI 10.1016/j.bcp.2020.113929 Human secretin
Reference 2
Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA.
Whitmore TE, Holloway JL, Lofton-Day CE, Maurer MF, Chen L, Quinton TJ, Vincent JB, Scherer SW, Lok S
Cytogenetics and cell genetics · 2000 · Journal Article
current
PMID 11060443 DOI 10.1159/000015658 Human secretin

Study models of these references

What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.

Reference	Study models
Dong M et al. 2020	Study models reported: in vitro · from the abstract
Whitmore TE et al. 2000	Chemical, structural or analytical study; no biological model reported

Record history

Published 2026-10-21.

No changes to this record's content have been recorded since publication.

Each entry names the parts of this record that changed on that date. Changes to links between records and to catalogue links are not listed. This history covers the tracked record fields; study findings are not listed here.

Cite this record: Purely Peptides Research Library. Human secretin. Published 2026-10-21. https://purelypeptides.org/research/compounds/secretin/

Methodology & citation verification

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