Semax
10mg
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10), with a C-terminal Pro-Gly-Pro tripeptide extension conferring enhanced metabolic stability. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax is classified as a nootropic and neuroprotective agent in Russian pharmacopoeia. It has been studied extensively for cognitive enhancement, neuroprotection following ischemic events, and modulation of neurotrophic factor expression.
Pricing
Mechanism of Action
Semax upregulates brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and TrkB receptor expression in hippocampal and cortical regions. It modulates the melanocortin system via MC4R interaction without significant adrenal steroidogenic activity at nootropic doses. Additional mechanisms include attenuation of nitric oxide synthase activity in ischemic tissue, modulation of serotonergic and dopaminergic neurotransmission, and enhancement of cholinergic signaling relevant to memory consolidation.
Properties
Molecular Formula
C₃₉H₅₁N₉O₁₀S
Molecular Weight
813.93 Da
Sequence
Met-Glu-His-Phe-Pro-Gly-Pro
Half-Life
~3-5 minutes (peripheral), extended CNS activity
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Research Applications
References & Citations
(3)Nootropic and analgesic effects of Semax following different routes of administration
Levitskaya NG, Glazova NY, Sebentsova EA, et al.
Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus
Dolotov OV, Karpenko EA, Inozemtseva LS, et al.
The neuroprotective effects of Semax in the acute period of ischemic stroke
Gusev EI, Skvortsova VI, Izykenova GA, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.