Compound monograph
Semax
Semax is a synthetic heptapeptide corresponding to residues 4 to 7 of adrenocorticotropic hormone extended at the C-terminus with the tripeptide Pro-Gly-Pro.
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Identity & nomenclature
Semax is a synthetic heptapeptide corresponding to residues 4 to 7 of adrenocorticotropic hormone extended at the C-terminus with the tripeptide Pro-Gly-Pro.
The PubChem record describes Semax as ACTH(4-7) extended with Pro-Gly-Pro. The catalog separately lists N-acetyl semax amidate, which carries an N-terminal acetyl group and a C-terminal amide; that is a distinct molecule with a different formula, mass, and registry number, and it is not covered by this record.
Declared aliases and development codes: ACTH(4-7)-Pro-Gly-Pro.
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Molecular properties
| Molecular formula | C37H51N9O10S |
|---|---|
| Molecular mass | 813.9 Da |
| CAS Registry Number | 80714-61-0 |
| PubChem CID | 9811102 |
| UNII | I5FAL2585H |
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Structural characteristics
The design follows a fragment-plus-extension pattern: a short sequence taken from a larger endogenous regulatory peptide, extended with a C-terminal Pro-Gly-Pro tripeptide. Selank, also in this library, was constructed on the same pattern from a different parent fragment.
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Molecular targets & mechanisms
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Analytical considerations
The single sulfur atom corresponds to the methionine at the first position of the ACTH(4-7) fragment and is relevant to oxidation-related degradation. Because the catalog also carries an N-acetylated, C-amidated variant, identity methods must distinguish the two forms rather than reporting a single Semax mass.
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Methodology & citation verification
Reference identity is checked against official PubMed metadata. Local deterministic receipts bind each normalized title and canonical metadata record to its verification date. Scientific values remain absent when an authoritative source has not been verified.
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