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Catalog/Tesamorelin
Tesamorelin
#1049
Lyophilized Peptide

Tesamorelin 5mg

Tesamorelin (TH9507) is a synthetic analog of human GHRH(1-44)-NH2 with a trans-3-hexenoyl moiety attached to the N-terminal Tyr1 residue. The cited preclinical study examined resistance to enzymatic deactivation, plasma degradation and GH/IGF-1 responses. This listing contains 5mg of lyophilized material. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.

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Single (5mg)$39.99

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Mechanism of Action

Ferdinandi et al. (2007) characterized TH9507, the modified GHRH analog tesamorelin. Its N-terminal trans-3-hexenoyl modification conferred resistance to DPP-IV deactivation and slowed peptide degradation in rat, dog and human plasma in vitro. GH and IGF-1 responses were also measured in preclinical animal studies; those findings do not establish preservation of physiological GH pulsatility.

Properties

CAS Number

218949-48-5

Molecular Formula

C₂₂₁H₃₆₆N₇₂O₆₇S

Molecular Weight

5135.86 Da

Half-Life

~21-45 min (dog plasma)

Storage

Store lyophilized at 2-8°C. Reconstituted at 2-8°C, use within 14 days.

Shipping & Delivery

  • Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
  • US shipping from $5. Free Priority on orders $100+ (before discounts).
  • Plain, unmarked packaging — no branding or product names on the outside.
  • Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
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Quality & Testing

  • No third-party certificate has been published for this compound yet.
  • USA-based; dispatched from Phoenix, Arizona.
  • Supplied strictly for in-vitro laboratory research — not for human use.

Certificates are published for each lot we have tested — see the 14 published so far.

Research Applications

1Plasma peptide-degradation assays
2N-terminal modification and DPP-IV resistance comparisons
3Preclinical GH and IGF-1 response characterization

References & Citations

(1)
1

Non-clinical pharmacology and safety evaluation of TH9507, a human growth hormone-releasing factor analogue

Ferdinandi ES, Brazeau P, High K, et al.

Basic Clin Pharmacol Toxicol (2007)PMID: 17214611 DOI

Research Use Only

This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.

Research reference

A published identity, mechanism, and bibliography record corresponds to this catalog entry.

Research reference: Tesamorelin

More references from the Research Library (4)

Further papers cited in the Library's Tesamorelin record, each checked against PubMed. They describe the compound in research settings and are not statements about this product. See the full record for its identity, structure and complete bibliography.

  1. Tesamorelin.

    Grunfeld C, Dritselis A, Kirkpatrick P

    Nature reviews. Drug discovery (2011)News itemPMID 21283099
  2. Tesamorelin, a human growth hormone releasing factor analogue.

    Wang Y, Tomlinson B

    Expert opinion on investigational drugs (2009)Review articlePMID 19243281
  3. Drug evaluation: tesamorelin, a synthetic human growth hormone releasing factor.

    Tomlinson B

    Current opinion in investigational drugs (London, England : 2000) (2006)Review articlePMID 17086939
  4. Population pharmacokinetic analysis of tesamorelin in HIV-infected patients and healthy subjects.

    González-Sales M, Barrière O, Tremblay PO, et al.

    Clinical pharmacokinetics (2015)Human participants (interventional)PMID 25358450