commonly confused
GHK is the free tripeptide; GHK-Cu is a copper coordination species. Their molecular identities and registry numbers are distinct.
01
| Recorded field | GHK (Prezatide) | GHK-Cu |
|---|---|---|
| Canonical name | Prezatide | Prezatide copper |
| Aliases | GHK; Glycyl-L-histidyl-L-lysine; Tripeptide-1 | Copper tripeptide-1; GHK copper; Cu-GHK |
| Development codes | NSC-379527 | not recorded |
| CAS | 49557-75-7 | 89030-95-5 |
| UNII | 39TG2H631E | 6BJQ43T1I9 |
| PubChem CID | 73587 | 10111685 |
| Molecular formula | C14H24N6O4 | C14H22CuN6O4 |
| Molecular weight (Da) | 340.38 | 401.91 |
| Sequence length (residues) | 3 | not recorded |
| Terminal modifications | not recorded | not recorded |
| Structural modifications | not recorded | not recorded |
GHK, GHK-Cu and Pal-GHK are three different substances: an uncomplexed peptide, a copper coordination species, and a covalently lipidated derivative. CAS 49557-75-7 belongs to THIS entry, the free tripeptide. The copper complex is 89030-95-5. That distinction has practical consequences — certificates of analysis in this market have carried the free-tripeptide number on copper-complex product, which describes the wrong substance.
GHK-Cu is a trade and literature name for the Cu(II) complex of the tripeptide glycyl-L-histidyl-L-lysine. The free tripeptide and the copper complex are distinct molecular records with different formulas, masses, and registry numbers: the free peptide is CAS 49557-75-7 (INN prezatide), and the copper complex is CAS 89030-95-5 (prezatide copper). Material sold under the name GHK-Cu should be identified against the intended species. Public databases do not agree on the complex: searching the name GHK-Cu in PubChem returns several distinct structures at 400.90, 401.91, 402.92, 403.92, 742.3 and 744.3, differing in how many protons the ligand has lost and in peptide-to-copper stoichiometry. The formula and mass recorded here are those the FDA substance registry gives for UNII 6BJQ43T1I9, prezatide copper, under CAS 89030-95-5, and match the CAS index name for that substance, which describes the ligand as lysinato(2-) - a doubly deprotonated ligand giving a neutral Cu(II) complex.
02
An aligned one-letter sequence is not recorded for this pair. The stored modification and sequence notes are shown below.
03
These lists show the links recorded in each monograph. An unlisted link does not establish its absence from the molecule’s biology.
not recorded
not recorded
04
not recorded
not recorded
05
Laussac JP, Haran R, Sarkar B
The Biochemical journal · 1983-02-01 · Journal Article
Lane TF, Iruela-Arispe ML, Johnson RS, Sage EH
The Journal of cell biology · 1994-05 · Journal Article
06