parent and analog
These records share the seven-residue Semax sequence. The amidate record specifies additional N-terminal acetyl and C-terminal amide groups.
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| Recorded field | Semax | N-Acetyl Semax Amidate |
|---|---|---|
| Canonical name | Semax | N-Acetyl Semax Amidate |
| Aliases | ACTH(4-7)-Pro-Gly-Pro | not recorded |
| Development codes | not recorded | not recorded |
| CAS | 80714-61-0 | not recorded |
| UNII | I5FAL2585H | not recorded |
| PubChem CID | 9811102 | 172638603 |
| Molecular formula | C37H51N9O10S | C39H54N10O10S |
| Molecular weight (Da) | 813.9 | 855 |
| Sequence length (residues) | 7 | 7 |
| Terminal modifications | not recorded | N-terminal acetylation at Met1; C-terminal amide at Pro7 |
| Structural modifications | not recorded | not recorded |
The PubChem record describes Semax as ACTH(4-7) extended with Pro-Gly-Pro. The catalog separately lists N-acetyl semax amidate, which carries an N-terminal acetyl group and a C-terminal amide; that is a distinct molecule with a different formula, mass, and registry number, and it is not covered by this record. Much of the published literature instead describes Semax as an ACTH(4-10) analogue. Both descriptions refer to the same molecule: Semax retains ACTH residues 4 to 7 (Met-Glu-His-Phe) and substitutes Pro-Gly-Pro for residues 8 to 10 (Arg-Trp-Gly). This record uses the ACTH(4-7)-plus-Pro-Gly-Pro form because it states the composition of the molecule rather than the fragment it was designed from.
The complete name specifies both terminal groups. A bare N-acetyl Semax label does not specify the C-terminal group and is not an alias here. Acetate salt terminology does not establish covalent N-acetylation. PubChem CID 172638603 represents the recorded amidate structure. No CAS or UNII is assigned here because no authoritative assignment was verified.
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Positions are numbered from each stored sequence’s first residue. Highlighted cells differ or extend beyond the other chain; a dash indicates no aligned residue. One-letter notation does not encode terminal groups or stereochemistry. Read the recorded notes below.
| Semax | 1M | 2E | 3H | 4F | 5P | 6G | 7P |
|---|---|---|---|---|---|---|---|
| N-Acetyl Semax Amidate | 1M | 2E | 3H | 4F | 5P | 6G | 7P |
The stored one-letter residue sequences match at every position. Recorded terminal and structural features remain separate identity fields.
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These lists show the links recorded in each monograph. An unlisted link does not establish its absence from the molecule’s biology.
not recorded
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Vanhee C, Francotte A, Janvier S, Deconinck E
Drug testing and analysis · 2020-01-29 · Journal Article
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