Compound monograph

N-Acetyl Selank Amidate

N-Acetyl Selank Amidate is the Selank heptapeptide with an acetyl group on the N-terminal threonine residue and an amide at the C-terminal proline. These covalent terminal changes define a distinct molecule.

Published: 2026-09-28Last updated: 2026-10-15Literature/identifier verification: 2026-09-28

Regulatory peptide fragment analogs

Identity & nomenclature

The complete name specifies both terminal groups. A bare N-acetyl Selank label does not specify the C-terminal group and is not an alias here. Acetate salt terminology does not establish covalent N-acetylation. PubChem CID 133082488 and UNII J3PM702O93 describe the N-acetyl Selank free acid, C35H59N11O10, and are not identifiers for this amidate. No CAS, PubChem CID or UNII is assigned here because no matching authoritative record was verified.

Molecular properties

Molecular formula	C35H60N12O9
Molecular mass	792.9 Da
One-letter sequence	TKPRPGP
Three-letter sequence	Thr–Lys–Pro–Arg–Pro–Gly–Pro
Terminal groups	N-terminal acetylation at Thr1; C-terminal amide at Pro7

The seven residue positions are unchanged from Selank. In shorthand, Ac and NH2 denote the N-terminal acetyl and C-terminal amide groups; they are not additional residues.

Structural characteristics

The residue sequence preserves the tuftsin-plus-Pro-Gly-Pro construction of Selank. N-terminal acetylation adds C2H2O to the free-terminal parent; C-terminal amidation adds H and N and removes O. Together the changes add C2H3N and yield C35H60N12O9. The direct parent link identifies this structural relationship.

Terminal features: N-terminal acetylation at Thr1, C-terminal amide at Pro7.

Molecular targets & mechanisms

Analytical considerations

Table 1 of Vanhee et al. (PMID 31667971) corroborates the C35H60N12O9 formula for a custom-synthesized reference standard from Thermo Fisher Scientific. The sequence column describes the ordered standard, not a sequence established for a seized amidate sample. This citation supplies formula corroboration only for this record; the Selank-specific rLys-C discrimination does not apply here. Table 1 reports 792.4606 Da monoisotopic mass. The library records 792.9 Da average mass, derived from the formula using its conventional atomic weights. The paper is not the original source of the name-to-sequence mapping.

Disagreements and mix-ups

Points where sources disagree about this compound's identity, or where a name or form is easily confused with another, as noted in this record. The discrepancy register quotes the passage for each one.

Often mixed up · Salt or form
Acetate salt vs a covalent N-acetyl group
Also noted in Macimorelin, N-Acetyl Semax Amidate
Often mixed up · Name or substance
"N-acetyl Selank" without the amidate
Often mixed up · Registry identifier
Identifiers that belong to N-acetyl Selank free acid

What the studies reported

No verified findings are published for this record under Content Policy v1.

Verified bibliography

Cited studies by type

The one paper this record cites, counted by the kind of work each reports. A count is the size of this record's selection, not of the research that exists, and says nothing about results, safety, effectiveness or approval.

Chemical, structural or analytical; no biological model1

A paper can report more than one kind of work. Each count opens those papers in the bibliography. Compare every record on the Evidence Map.

Reference 1
The occurrence of putative cognitive enhancing research peptides in seized pharmaceutical preparations: An incentive for controlling agencies to prepare for future encounters of the kind.
Vanhee C, Francotte A, Janvier S, Deconinck E
Drug testing and analysis · 2020-01-29 · Journal Article
current
PMID 31667971 DOI 10.1002/dta.2717 Selank Semax N-Acetyl Selank Amidate N-Acetyl Semax Amidate

Study models of these references

What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.

Reference	Study models
Vanhee C et al. 2020	Chemical, structural or analytical study; no biological model reported

Compare

Selank vs N-Acetyl Selank Amidate: Sequence and Identity

Catalog listing

Record history

Published 2026-09-28.

2026-10-15: Sequence and structure

Each entry names the parts of this record that changed on that date. Changes to links between records and to catalogue links are not listed. This history covers the tracked record fields; study findings are not listed here.

Cite this record: Purely Peptides Research Library. N-Acetyl Selank Amidate. Published 2026-09-28; updated 2026-10-15. https://purelypeptides.org/research/compounds/n-acetyl-selank-amidate/

Methodology & citation verification

Reference identity is checked against official PubMed metadata. Local deterministic receipts bind each normalized title and canonical metadata record to its verification date. Scientific values remain absent when an authoritative source has not been verified.

Read the full methodology →