Compound monograph
SHLP6
SHLP6 is a 20-residue peptide assigned to the mitochondrial 16S rRNA region and distinguished from other SHLP members by its sequence and reported cellular response.
01
Identity & nomenclature
SHLP6 is a 20-residue peptide assigned to the mitochondrial 16S rRNA region and distinguished from other SHLP members by its sequence and reported cellular response.
SHLP6 is twenty residues; descriptions that give all SHLPs a common length range are wrong. PubChem CID 16208939 encodes the free 20-residue sequence MLDQDIPMVQPLLKVRLFND; its CAS 368431-25-8 synonym remains independently unconfirmed, and no exact GSRS UNII was found. It is neither a truncated humanin nor interchangeable with SHLP2 or SHLP3, and it does not behave like them — see structuralNotes.
Canonical name: Small humanin-like peptide 6.
Declared aliases and development codes: SHLP-6.
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Molecular properties
| Molecular formula | C107H177N27O30S2 |
|---|---|
| Molecular mass | 2385.9 Da |
| PubChem CID | 16208939 |
| One-letter sequence | MLDQDIPMVQPLLKVRLFND |
| Terminal groups | Free N-terminus; Free C-terminal carboxyl |
Twenty residues, free at both termini. TWO methionines, at positions 1 and 8, and NO cysteine — so it carries two sulfur atoms without any thiol.
03
Structural characteristics
The discovery comparison found different cellular responses across the SHLP series: SHLP6 increased apoptosis in the assay where SHLP2 and SHLP3 reduced it. Family membership does not establish a common cellular effect. Separately, SHLP6 and humanin showed strong synonymous codon bias and sequence conservation, consistent with amino-acid sequence constraint. This support does not extend to SHLP2 or SHLP3. No direct receptor or molecular target is established here.
Terminal features: Free N-terminus, Free C-terminal carboxyl.
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Molecular targets & mechanisms
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Analytical considerations
Fragmentation should cover methionine 8 and the C-terminal aspartate. With two methionines, singly and doubly oxidised species are relevant identity impurities rather than incidental ones. The peptide contains no cysteine, so any proposed disulfide structure contradicts this sequence outright. Antibody detection and coding-sequence conservation each establish something real and neither establishes intact endogenous termini, which remain unknown.
Disagreements and mix-ups
Points where sources disagree about this compound's identity, or where a name or form is easily confused with another, as noted in this record. The discrepancy register quotes the passage for each one.
Sources disagree · this Library follows one source · Residue count
Length of SHLP6Often mixed up · Name or substance
SHLPs are not humanin fragments
What the studies reported
Each finding describes one cited study in its stated model. These observations are specific to that study and do not establish effects in other settings.
Cell and tissue studies
Murine NIT-1 β-cells and human prostate cancer 22Rv1 cells under serum starvation
In murine NIT-1 β-cells and human prostate cancer 22Rv1 cells under serum starvation, the study observed significantly increased apoptosis with SHLP6.
Reference [1]C57BL/6 mouse tissue immunoblot assay
Using a C57BL/6 mouse tissue immunoblot assay, the study detected SHLP6 in liver and kidney.
Reference [1]
Computational studies
Comparative vertebrate mitochondrial coding-sequence analysis
Using comparative vertebrate mitochondrial coding-sequence analysis, the study reported strong synonymous codon bias and sequence conservation for SHLP6.
Reference [2]
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Verified bibliography
Cited studies by type
The 3 papers this record cites, counted by the kind of work each reports. A count is the size of this record's selection, not of the research that exists, and says nothing about results, safety, effectiveness or approval.
A paper can report more than one kind of work. Each count opens those papers in the bibliography. Compare every record on the Evidence Map.
Reference 1
Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers.Cobb LJ, Lee C, Xiao J, Yen K, Wong RG, Nakamura HK, Mehta HH, Gao Q, Ashur C, Huffman DM, Wan J, Muzumdar R, Barzilai N, Cohen P
Aging · 2016-04 · Journal Article
currentReference 2
Evidence of natural selection in the mitochondrial-derived peptides humanin and SHLP6.Gruschus JM, Morris DL, Tjandra N
Scientific reports · 2023-08-29 · Journal Article
currentReference 3
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P
Cell metabolism · 2015-03-03 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Cobb LJ et al. 2016 | Study models reported: in vitro; animal (rat, mouse) · from the full text |
| Gruschus JM et al. 2023 | Computational analysis |
| Lee C et al. 2015 | Study models reported: in vitro; animal (mouse) · from the full text |
Record history
Published 2026-09-16.
- : Identity and nomenclature
Each entry names the parts of this record that changed on that date. Changes to links between records and to catalogue links are not listed. This history covers the tracked record fields; study findings are not listed here.
Cite this record: Purely Peptides Research Library. SHLP6. Published 2026-09-16; updated 2026-10-13. https://purelypeptides.org/research/compounds/shlp6/
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Methodology & citation verification
Reference identity is checked against official PubMed metadata. Local deterministic receipts bind each normalized title and canonical metadata record to its verification date. Scientific values remain absent when an authoritative source has not been verified.
Read the full methodology →