Compound Directory

Linear melanocortin analogs

Melanotan I (Afamelanotide)

Melanotan I · Melanotan-1 · MT-I · MT-1 · NDP-MSH · NDP-alpha-MSH · CUV1647 · MBJ05

Afamelanotide, widely supplied as Melanotan I, is a linear thirteen-residue analog of alpha-melanocyte-stimulating hormone carrying norleucine and D-phenylalanine substitutions.

Melanocortin receptor ligands

alpha-MSH

α-MSH · alpha-MSH · alpha-melanotropin · Melanotropin alpha

alpha-MSH is the endogenous thirteen-residue melanocortin peptide hormone from which several of the synthetic compounds in this library are derived.

Amylin and calcitonin receptor agonists

Amylin (human IAPP)

Human islet amyloid polypeptide · IAPP · hIAPP · Amlintide

Amylin is the endogenous 37-residue human pancreatic peptide hormone, co-secreted with insulin, from which pramlintide and cagrilintide are both derived.

Growth hormone secretagogues

Anamorelin

ONO-7643 · RC-1291 · ST-1291

Anamorelin is a nonpeptide small-molecule agonist at the ghrelin receptor, structurally unrelated to the peptide secretagogues that share its target.

Regenerative peptides

BPC-157

Bepecin · BPC 15

BPC-157 is a synthetic fifteen-residue peptide corresponding to a partial sequence of body protection compound, a protein reported to have been isolated from human gastric juice.

Cyclic melanocortin analogs

PT-141 (Bremelanotide)

Bremelanotide · PT 141 · PT-141 free base · PT-141

PT-141, canonically bremelanotide, is a synthetic cyclic heptapeptide melanocortin receptor agonist, structurally the C-terminal free acid of the Melanotan II lactam scaffold.

Amylin and calcitonin receptor agonists

Cagrilintide

AM833 · AM-833 · NNC0174-0833

Cagrilintide is a long-acting synthetic amylin analog, lipidated and disulfide-cyclized, characterised at the calcitonin receptor and at amylin receptor complexes.

ARA-290

ARA 290 · Cibinetida · Cibinetidum · PHBSP

Cibinetide is a synthetic peptide corresponding to a surface region of erythropoietin, characterized in the literature as a selective agonist at a heteromeric receptor complex distinct from the erythropoietin receptor homodimer.

GHRH analogs

CJC-1295

CJC 1295

CJC-1295 designates a tetrasubstituted analog of human growth hormone-releasing factor residues 1 to 29, reported to act at the GRF receptor on the anterior pituitary.

Melanocortin fragment peptides · Melanocortin receptor ligands

Cosyntropin (ACTH 1-24)

Tetracosactide · ACTH(1-24) · alpha 1-24 corticotropin

Cosyntropin is the synthetic 1-24 fragment of adrenocorticotropic hormone, the melanocortin ligand of the MC2R branch.

DSIP

DSIP · Delta-sleep-inducing peptide

DSIP is a synthetic nonapeptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, first isolated and sequenced in 1978.

Epitalon

Epithalon · Epithalone · AEDG peptide

Epitalon is a synthetic tetrapeptide, Ala-Glu-Asp-Gly, described in the source literature as a short peptide designed following work on pineal tissue extracts.

Growth hormone secretagogues

Examorelin (Hexarelin)

Hexarelin · EP-23905 · MF-6003

Examorelin, widely supplied as hexarelin, is a synthetic hexapeptide growth hormone secretagogue carrying a 2-methylated D-tryptophan.

GLP-1 receptor peptide analogs

Exenatide

Exendin-4

Exenatide is a 39-residue peptide with an N-terminal histidine and a C-terminal serine amide, originally isolated from Heloderma suspectum venom and characterized as a member of the glucagon superfamily.

Growth hormone secretagogues

Human Octanoyl-Ghrelin

Lenomorelin · Human acyl-ghrelin · Acyl-ghrelin

Human octanoyl-ghrelin is the endogenous 28-residue acylated peptide ligand of the ghrelin receptor, carrying an n-octanoyl ester on serine 3.

Growth hormone secretagogues

GHRP-6

Hexapeptide-2 · Growth hormone-releasing peptide-6

GHRP-6 is a synthetic hexapeptide with a C-terminal amide, characterized as an agonist at the growth hormone secretagogue receptor.

Incretin and glucagon receptor ligands

Glucagon

Glucagon(1-29)

Glucagon is the endogenous 29-residue pancreatic hormone and the native ligand of the glucagon receptor.

Incretin and glucagon receptor ligands

GLP-1(7-36) amide

GLP-1(7-36)amide · GLP-1 7-36 amide · Insulinotropin

GLP-1(7-36) amide is an endogenous processing form of glucagon-like peptide-1 and the native ligand against which the GLP-1 receptor agonists in this library are compared.

Incretin and glucagon receptor ligands

GLP-1(7-37)

GLP-1 7-37 · GLP-I(7-37)

GLP-1(7-37) is an endogenous processing form of glucagon-like peptide-1 retaining a C-terminal glycine, and the structural reference for several acylated GLP-1 analogs.

Incretin and glucagon receptor ligands

GIP(1-42)

GIP · Gastric inhibitory polypeptide · Glucose-dependent insulinotropic peptide

GIP is a 42-residue endogenous incretin hormone and the native ligand of the GIP receptor.

Thymosin-related peptides

Ac-SDKP (Goralatide)

Ac-SDKP · Seraspenide · N-acetyl-seryl-aspartyl-lysyl-proline

Ac-SDKP is the acetylated N-terminal tetrapeptide of thymosin beta-4, generated from the parent by sequential enzymatic processing.

Growth hormone secretagogues

Ipamorelin

NNC 26-0161

Ipamorelin is a synthetic pentapeptide with a C-terminal amide, characterized in its original report as a growth hormone secretagogue acting through a GHRP-like receptor rather than the GHRH receptor.

Kisspeptins

Kisspeptin-10

KP-10 · Metastin (45-54) · Human metastin 45-54

Kisspeptin-10 is the amidated ten-residue C-terminal fragment represented by the human KISS1-derived kisspeptin sequence. Foundational records identify KISS1 peptides as ligands of GPR54, now KISS1R.

Melanocortin fragment peptides

KPV

Lys-Pro-Val · alpha-MSH (11-13) · MSH (11-13)

KPV is a synthetic tripeptide, Lys-Pro-Val, corresponding to the C-terminal three residues of alpha-melanocyte-stimulating hormone.

Matrikine-derived peptides

KTTKS (Pentapeptide-4)

Pentapeptide-4 · Collagen pentapeptide

KTTKS is the unmodified pentapeptide from type I procollagen that forms the peptide backbone of the palmitoylated cosmetic ingredient Matrixyl.

GLP-1 receptor peptide analogs

Liraglutide

NN2211

Liraglutide is an acylated peptide analog of glucagon-like peptide-1, characterized against the GLP-1 receptor.

Growth hormone secretagogues

Macimorelin

AEZS-130 · JMV 1843 · EP-1572

Macimorelin is an orally active gem-diamino peptidomimetic agonist at the ghrelin receptor.

Multi-receptor incretin analogs

Mazdutide

IBI362 · IBI-362 · LY3305677 · LY-3305677 · IBI362 · LY3305677

Mazdutide is a lipidated synthetic peptide classified as a GLP-1 and glucagon receptor dual agonist, built on an oxyntomodulin-derived backbone.

Cyclic melanocortin analogs

Melanotan II

Melanotan-II · MT-II · MT-2

Melanotan II is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone, closed by a lactam bridge between an aspartate and a lysine side chain.

Mitochondrial-derived peptides

MOTS-c

Mitochondrial open reading frame of the 12S rRNA-c

MOTS-c is a sixteen-amino-acid peptide encoded by a short open reading frame within the mitochondrial 12S rRNA, rather than by the nuclear genome.

Nonpeptide receptor agonists

Orforglipron

LY3502970

Orforglipron is a synthetic nonpeptide molecule characterized as a selective, high-affinity agonist at the human GLP-1 receptor.

Incretin and glucagon receptor ligands

Oxyntomodulin

OXM · Glucagon-37

Oxyntomodulin is an endogenous proglucagon-derived peptide containing the complete glucagon sequence plus an eight-residue C-terminal extension, with reported activity at both the GLP-1 and glucagon receptors.

Neurotrophic peptide mimetics

P021 (P21)

P21 · P-21 · Peptide 021

P021 is a small acetylated tetrapeptide carrying an adamantane-derived C-terminal extension, designed as a CNTF-derived peptide mimetic.

Matrikine-derived peptides

Matrixyl

Pal-KTTKS · Palmitoyl-KTTKS · Palmitoyl pentapeptide-3

Palmitoyl pentapeptide-4 is the pentapeptide KTTKS with an N-terminal palmitoyl group, corresponding to a fragment sequence of type I procollagen.

Matrikine-derived peptides

Pal-GHK (Palmitoyl Tripeptide-1)

Pal-GHK · N-palmitoyl-GHK · C16-GHK · Palmitoyl oligopeptide

Pal-GHK is the N-palmitoylated derivative of the GHK tripeptide, used as a cosmetic ingredient and as an analytical internal standard.

Regulatory peptide fragment analogs

PE 22-28

PE(22-28) · Sortilin propeptide (22-28)

PE 22-28 is a synthetic heptapeptide corresponding to residues 22 to 28 of the sortilin propeptide. It is not a fragment of spexin; see the nomenclature note.

Growth hormone secretagogues

Pralmorelin (GHRP-2)

GHRP-2 · Growth hormone-releasing peptide-2 · KP-102

Pralmorelin is a synthetic hexapeptide growth hormone secretagogue acting at the ghrelin receptor, containing three D-configured residues and a naphthylalanine substitution.

Amylin and calcitonin receptor agonists

Pramlintide

AC137

Pramlintide is an engineered analog of human amylin carrying three proline substitutions, designed to address the aggregation behaviour of the native human sequence.

Copper-binding peptides · Matrikine-derived peptides

GHK (Prezatide)

GHK · Glycyl-L-histidyl-L-lysine · Tripeptide-1 · NSC-379527

GHK is the uncomplexed tripeptide ligand of the GHK-copper complex, identified in 1977 as a growth-modulating tripeptide from human plasma.

Copper-binding peptides · Matrikine-derived peptides

GHK-Cu

Copper tripeptide-1 · GHK copper · Cu-GHK

Prezatide copper is the Cu(II) coordination complex of the tripeptide glycyl-L-histidyl-L-lysine. The copper ion is part of the declared molecular identity and distinguishes this record from the free tripeptide.

Multi-receptor incretin analogs

Retatrutide

LY3437943

Retatrutide, development code LY3437943, is a single peptide characterized as an agonist at GCGR, GIPR, and GLP-1R in its discovery record.

Regulatory peptide fragment analogs

Selank

Selanc · Tuftsin-Pro-Gly-Pro

Selank is a synthetic heptapeptide consisting of the tetrapeptide tuftsin extended at the C-terminus with the tripeptide Pro-Gly-Pro.

GLP-1 receptor peptide analogs

Semaglutide

NN9535 · NNC 0113-0217

Semaglutide is an acylated peptide analog of glucagon-like peptide-1. Its discovery record identifies two amino-acid substitutions and derivatization at Lys26.

Regulatory peptide fragment analogs

Semax

ACTH(4-7)-Pro-Gly-Pro

Semax is a synthetic heptapeptide corresponding to residues 4 to 7 of adrenocorticotropic hormone extended at the C-terminus with the tripeptide Pro-Gly-Pro.

GHRH analogs

Sermorelin

GRF(1-29) · Sermorelina · Sermorelinum

Sermorelin is the synthetic peptide corresponding to residues 1 to 29 of human growth hormone-releasing factor, the unmodified parent fragment from which several longer-acting analogs are derived.

Cyclic melanocortin analogs · Melanocortin receptor ligands

Setmelanotide

RM-493 · BIM-22493 · IRC-022493

Setmelanotide is a synthetic disulfide-cyclized octapeptide characterised as an MC4R-preferring melanocortin receptor agonist.

Cyclic melanocortin analogs · Melanocortin receptor ligands

SHU9119

SHU-9119 · SHU 9119

SHU9119 is a cyclic lactam melanocortin analog whose receptor behaviour is subtype-dependent: antagonist at some melanocortin receptors and agonist at others.

Multi-receptor incretin analogs

Survodutide

BI 456906 · BI-456906 · BI 456906

Survodutide is a lipidated synthetic peptide agonist at both the GLP-1 receptor and the glucagon receptor, built on a modified glucagon-family backbone with a branched side-chain linker.

GHRH analogs

Tesamorelin

TH9507

Tesamorelin is a synthetic analog of human growth hormone-releasing factor, characterized in the literature as a GRF analog acting at the GHRH receptor.

Melanocortin receptor ligands

THIQ

THIQ is a nonpeptide small-molecule agonist at the melanocortin-4 receptor, included here as the nonpeptide comparator to the melanocortin peptides.

Thymosin-related peptides

Thymosin beta-4

Thymosin b4 · Tbeta4 · TB4

Thymosin beta-4 is an N-terminally acetylated peptide originally isolated from a thymic tissue fraction and subsequently characterized as a G-actin-sequestering peptide.

Multi-receptor incretin analogs

Tirzepatide

LY3298176

Tirzepatide is a fatty-acid-modified synthetic peptide characterized in its discovery record as having agonist activity at both the GIP receptor and the GLP-1 receptor.