Molecular mechanism
GHRH receptor
A class B G-protein-coupled receptor expressed on anterior pituitary somatotrophs. Synthetic growth hormone-releasing factor analogs are characterized by their activity at this receptor.
See this target on the receptor map
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Neutral molecular overview
A class B G-protein-coupled receptor expressed on anterior pituitary somatotrophs. Synthetic growth hormone-releasing factor analogs are characterized by their activity at this receptor.
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Target identifiers
- Gene symbols
- GHRHR
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Related compounds
Compound
CJC-1295
CJC-1295 designates a tetrasubstituted analog of human growth hormone-releasing factor residues 1 to 29, reported to act at the GRF receptor on the anterior pituitary.
Compound
Sermorelin
Sermorelin is the synthetic peptide corresponding to residues 1 to 29 of human growth hormone-releasing factor, the unmodified parent fragment from which several longer-acting analogs are derived.
Compound
Tesamorelin
Tesamorelin is a synthetic analog of human growth hormone-releasing factor, characterized in the literature as a GRF analog acting at the GHRH receptor.
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Related mechanisms
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Verified bibliography
Reference 1
Tesamorelin, a human growth hormone releasing factor analogue.Wang Y, Tomlinson B
Expert opinion on investigational drugs · 2009-03 · Review
currentReference 2
Population pharmacokinetic analysis of tesamorelin in HIV-infected patients and healthy subjects.González-Sales M, Barrière O, Tremblay PO, Nekka F, Mamputu JC, Boudreault S, Tanguay M
Clinical pharmacokinetics · 2015-03 · Journal Article
currentReference 3
Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog.Jetté L, Léger R, Thibaudeau K, Benquet C, Robitaille M, Pellerin I, Paradis V, van Wyk P, Pham K, Bridon DP
Endocrinology · 2005-04-07 · Journal Article
currentReference 4
Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA
The Journal of clinical endocrinology and metabolism · 2005-12-13 · Journal Article
currentReference 5
Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse.Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R
American journal of physiology. Endocrinology and metabolism · 2006-07-05 · Journal Article
currentReference 6
Drug evaluation: tesamorelin, a synthetic human growth hormone releasing factor.Tomlinson B
Current opinion in investigational drugs (London, England : 2000) · 2006-10 · Review
currentReference 7
currentReference 8
Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.Mayo KE
Molecular endocrinology (Baltimore, Md.) · 1992-10 · Journal Article
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Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Wang Y et al. 2009 | Review article |
| González-Sales M et al. 2015 | Study models reported: human participants (interventional) · from the abstract |
| Jetté L et al. 2005 | Study models reported: in vitro; animal (rat) · from the abstract |
| Teichman SL et al. 2005 | Study models reported: human participants (interventional) · from the abstract |
| Alba M et al. 2006 | Study models reported: animal (mouse) · from the abstract |
| Tomlinson B 2006 | Review article |
| Grunfeld C et al. 2011 | News item |
| Mayo KE 1992 | Study models reported: in vitro · from the abstract |
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Related glossary terms
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Related Purely Peptides research articles
No existing Research Article is mapped to this mechanism seed record.