Molecular mechanism
GHRH receptor
A class B G-protein-coupled receptor expressed on anterior pituitary somatotrophs. Synthetic growth hormone-releasing factor analogs are characterized by their activity at this receptor.
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Neutral molecular overview
A class B G-protein-coupled receptor expressed on anterior pituitary somatotrophs. Synthetic growth hormone-releasing factor analogs are characterized by their activity at this receptor.
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Target identifiers
- Gene symbols
- GHRHR
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Related compounds
Compound
CJC-1295
CJC-1295 designates a tetrasubstituted analog of human growth hormone-releasing factor residues 1 to 29, reported to act at the GRF receptor on the anterior pituitary.
Compound
Sermorelin
Sermorelin is the synthetic peptide corresponding to residues 1 to 29 of human growth hormone-releasing factor, the unmodified parent fragment from which several longer-acting analogs are derived.
Compound
Tesamorelin
Tesamorelin is a synthetic analog of human growth hormone-releasing factor, characterized in the literature as a GRF analog acting at the GHRH receptor.
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Related mechanisms
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Verified bibliography
- Tesamorelin, a human growth hormone releasing factor analogue.current
Wang Y, Tomlinson B
Expert opinion on investigational drugs · 2009-03 · Review
- Population pharmacokinetic analysis of tesamorelin in HIV-infected patients and healthy subjects.current
González-Sales M, Barrière O, Tremblay PO, Nekka F, Mamputu JC, Boudreault S, Tanguay M
Clinical pharmacokinetics · 2015-03 · Journal Article
- Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog.current
Jetté L, Léger R, Thibaudeau K, Benquet C, Robitaille M, Pellerin I, Paradis V, van Wyk P, Pham K, Bridon DP
Endocrinology · 2005-04-07 · Journal Article
- Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.current
Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA
The Journal of clinical endocrinology and metabolism · 2005-12-13 · Journal Article
- Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse.current
Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R
American journal of physiology. Endocrinology and metabolism · 2006-07-05 · Journal Article
- Drug evaluation: tesamorelin, a synthetic human growth hormone releasing factor.current
Tomlinson B
Current opinion in investigational drugs (London, England : 2000) · 2006-10 · Review
- current
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Related glossary terms
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Related Purely Peptides research articles
No existing Research Article is mapped to this mechanism seed record.