Molecular mechanism
Kisspeptin receptor
KISS1R is a G-protein-coupled receptor historically reported as GPR54 and AXOR12. Foundational records identify KISS1-derived peptides as its endogenous ligands.
See this target on the receptor map
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Neutral molecular overview
KISS1R is a G-protein-coupled receptor historically reported as GPR54 and AXOR12. Foundational records identify KISS1-derived peptides as its endogenous ligands.
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Target identifiers
No target identifier beyond the verified name and aliases is listed for this mechanism.
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Related compounds
Compound
Kisspeptin-10
Kisspeptin-10 is the amidated ten-residue C-terminal fragment represented by the human KISS1-derived kisspeptin sequence. Foundational records identify KISS1 peptides as ligands of GPR54, now KISS1R.
Compound
Kisspeptin-14
Kisspeptin-14 is a KISS1-derived peptide isolated from human placental extracts, containing kisspeptin-10 as its C-terminal decapeptide, and an agonist at the kisspeptin receptor.
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Related mechanisms
No related mechanism is declared in this seed record.
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Verified bibliography
Reference 1
Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M
Nature · 2001-05-31 · Journal Article
currentReference 2
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brézillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M
The Journal of biological chemistry · 2001-07-16 · Journal Article
currentReference 3
AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1.Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC
The Journal of biological chemistry · 2001-05-31 · Journal Article
currentReference 4
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Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Ohtaki T et al. 2001 | Study models reported: in vitro; in vivo (subject not stated) · from the abstract |
| Kotani M et al. 2001 | Study models reported: in vitro; animal (rat) · from the abstract |
| Muir AI et al. 2001 | Study models reported: in vitro · from the abstract |
| Tena-Sempere M 2006 | Review article |
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Related glossary terms
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Related Purely Peptides research articles
No existing Research Article is mapped to this mechanism seed record.