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Compound monograph

Kisspeptin-10

Kisspeptin-10 is the amidated ten-residue C-terminal fragment represented by the human KISS1-derived kisspeptin sequence. Foundational records identify KISS1 peptides as ligands of GPR54, now KISS1R.

Published: 2026-09-04Last updated: 2026-10-15Literature/identifier verification: 2026-08-23
Also known asKP-10Metastin (45-54)Human metastin 45-54
Kisspeptins

01

Identity & nomenclature

Kisspeptin-10 is the amidated ten-residue C-terminal fragment represented by the human KISS1-derived kisspeptin sequence. Foundational records identify KISS1 peptides as ligands of GPR54, now KISS1R.

KP-10 and metastin (45-54) identify the amidated ten-residue C-terminal fragment of the human KISS1-derived peptide sequence.

Declared aliases and development codes: KP-10, Metastin (45-54), Human metastin 45-54.

02

Molecular properties

Molecular formulaC63H83N17O14
Molecular mass1302.4 Da
CAS Registry Number374675-21-5
PubChem CID25240297
UNIIFS1N52VS3S
One-letter sequenceYNWNSFGLRF
Three-letter sequenceTyr–Asn–Trp–Asn–Ser–Phe–Gly–Leu–Arg–Phe
Terminal groupsFree N-terminus; C-terminal amidation

The PubChem molecular record represents the C-terminal phenylalanine as an amide.

03

Structural characteristics

The sequence terminates in an RF-amide motif shared by the KISS1-derived peptides described in the foundational receptor record.

Terminal features: Free N-terminus, C-terminal amidation.

04

Molecular targets & mechanisms

Kisspeptin receptor

KISS1R · GPR54 · AXOR12

KISS1R is a G-protein-coupled receptor historically reported as GPR54 and AXOR12. Foundational records identify KISS1-derived peptides as its endogenous ligands.

05

Analytical considerations

The verified bibliography includes a liquid chromatography high-resolution mass spectrometry record specific to kisspeptin-10 detection.

What the studies reported

Each finding describes one cited study in its stated model. These observations are specific to that study and do not establish effects in other settings.

Cell and tissue studies

  • Human serum incubations

    Colpaert et al. identified four kisspeptin-10 metabolites corresponding to fragments y9, y8, y7 and y5 after incubation in human serum in vitro.

    Reference [4]

  • KISS1R receptor complexes

    Shen et al. reported a cryo-EM structure of kisspeptin-10 bound to KISS1R in an in-vitro receptor complex and identified interactions with receptor extracellular loops.

    Reference [6]

06

Verified bibliography

Cited studies by type

The 7 papers this record cites, counted by the kind of work each reports. A count is the size of this record's selection, not of the research that exists, and says nothing about results, safety, effectiveness or approval.

A paper can report more than one kind of work. Each count opens those papers in the bibliography. Compare every record on the Evidence Map.

  1. Reference 1

    Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.

    Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M

    Nature · 2001-05-31 · Journal Article

    current
    PMID 11385580DOI 10.1038/35079135Kisspeptin-10KISS1R

  2. Reference 2

    The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.

    Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brézillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M

    The Journal of biological chemistry · 2001-07-16 · Journal Article

    current
    PMID 11457843DOI 10.1074/jbc.M104847200Kisspeptin-10Kisspeptin-14KISS1R

  3. Reference 3

    AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1.

    Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC

    The Journal of biological chemistry · 2001-05-31 · Journal Article

    current
    PMID 11387329DOI 10.1074/jbc.M102743200Kisspeptin-10KISS1R

  4. Reference 4

    Investigating the detection of the novel doping‐relevant peptide kisspeptin‐10 in urine using liquid chromatography high‐resolution mass spectrometry.

    Colpaert T, Risseeuw M, Deventer K, Van Eenoo P

    Biomedical chromatography : BMC · 2024-07-08 · Journal Article

    current
    PMID 38978171DOI 10.1002/bmc.5946Kisspeptin-10

  5. Reference 5

    GPR54 and kisspeptin in reproduction.

    Tena-Sempere M

    Human reproduction update · 2006-05-26 · Review

    current
    PMID 16731583DOI 10.1093/humupd/dml023Kisspeptin-10KISS1R

  6. Reference 6

    Structural basis for hormone recognition and distinctive Gq protein coupling by the kisspeptin receptor.

    Shen S, Wang D, Liu H, He X, Cao Y, Chen J, Li S, Cheng X, Xu HE, Duan J

    Cell reports · 2024-06-26 · Journal Article

    current
    PMID 38935498DOI 10.1016/j.celrep.2024.114389Kisspeptin-14Kisspeptin-10

  7. Reference 7

    Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty.

    Han SK, Gottsch ML, Lee KJ, Popa SM, Smith JT, Jakawich SK, Clifton DK, Steiner RA, Herbison AE

    The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005-12-07 · Journal Article

    current
    PMID 16339030PMC6725899DOI 10.1523/jneurosci.3328-05.2005Gonadorelin (GnRH-I)Kisspeptin-10

Study models of these references

What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.

ReferenceStudy models
Ohtaki T et al. 2001Study models reported: in vitro; in vivo (subject not stated) · from the abstract
Kotani M et al. 2001Study models reported: in vitro; animal (rat) · from the abstract
Muir AI et al. 2001Study models reported: in vitro · from the abstract
Colpaert T et al. 2024Study models reported: in vitro · from the abstract
Tena-Sempere M 2006Review article
Shen S et al. 2024Study models reported: in vitro · from the abstract
Han SK et al. 2005Study models reported: in vitro; animal (mouse) · from the full text

Compare

Catalog listing

Record history

Published 2026-09-04.

  • : Sequence and structure
  • : Sequence and structure
  • : References
  • : References

Each entry names the parts of this record that changed on that date. Changes to links between records and to catalogue links are not listed. This history covers the tracked record fields; study findings are not listed here.

Cite this record: Purely Peptides Research Library. Kisspeptin-10. Published 2026-09-04; updated 2026-10-15. https://purelypeptides.org/research/compounds/kisspeptin-10/

10

Methodology & citation verification

Reference identity is checked against official PubMed metadata. Local deterministic receipts bind each normalized title and canonical metadata record to its verification date. Scientific values remain absent when an authoritative source has not been verified.

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