Compound monograph
Kisspeptin-10
Kisspeptin-10 is the amidated ten-residue C-terminal fragment represented by the human KISS1-derived kisspeptin sequence. Foundational records identify KISS1 peptides as ligands of GPR54, now KISS1R.
01
Identity & nomenclature
Kisspeptin-10 is the amidated ten-residue C-terminal fragment represented by the human KISS1-derived kisspeptin sequence. Foundational records identify KISS1 peptides as ligands of GPR54, now KISS1R.
KP-10 and metastin (45-54) identify the amidated ten-residue C-terminal fragment of the human KISS1-derived peptide sequence.
Declared aliases and development codes: KP-10, Metastin (45-54), Human metastin 45-54.
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Molecular properties
| Molecular formula | C63H83N17O14 |
|---|---|
| Molecular mass | 1302.4 Da |
| CAS Registry Number | 374675-21-5 |
| PubChem CID | 25240297 |
| UNII | FS1N52VS3S |
| One-letter sequence | YNWNSFGLRF |
| Three-letter sequence | Tyr–Asn–Trp–Asn–Ser–Phe–Gly–Leu–Arg–Phe-NH2 |
The PubChem molecular record represents the C-terminal phenylalanine as an amide.
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Structural characteristics
The sequence terminates in an RF-amide motif shared by the KISS1-derived peptides described in the foundational receptor record.
Terminal features: C-terminal amidation.
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Molecular targets & mechanisms
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Analytical considerations
The verified bibliography includes a liquid chromatography high-resolution mass spectrometry record specific to kisspeptin-10 detection.
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Verified bibliography
- Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.current
Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M
Nature · 2001-05-31 · Journal Article
- The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.current
Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brézillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M
The Journal of biological chemistry · 2001-07-16 · Journal Article
- AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1.current
Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC
The Journal of biological chemistry · 2001-05-31 · Journal Article
- Investigating the detection of the novel doping‐relevant peptide kisspeptin‐10 in urine using liquid chromatography high‐resolution mass spectrometry.current
Colpaert T, Risseeuw M, Deventer K, Van Eenoo P
Biomedical chromatography : BMC · 2024-07-08 · Journal Article
- current
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Methodology & citation verification
Reference identity is checked against official PubMed metadata. Local deterministic receipts bind each normalized title and canonical metadata record to its verification date. Scientific values remain absent when an authoritative source has not been verified.
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