Compound class
Kisspeptins
Peptides derived from the KISS1 precursor that share a C-terminal RF-amide motif and bind the kisspeptin receptor.
01
Neutral class definition
Peptides derived from the KISS1 precursor that share a C-terminal RF-amide motif and bind the kisspeptin receptor.
02
Related compounds
Compound
Kisspeptin-10
Kisspeptin-10 is the amidated ten-residue C-terminal fragment represented by the human KISS1-derived kisspeptin sequence. Foundational records identify KISS1 peptides as ligands of GPR54, now KISS1R.
KP-10 · Metastin (45-54) · Human metastin 45-54
Compound
Kisspeptin-14
Kisspeptin-14 is a KISS1-derived peptide isolated from human placental extracts, containing kisspeptin-10 as its C-terminal decapeptide, and an agonist at the kisspeptin receptor.
KP-14 · Metastin(41-54)
03
Related molecular mechanisms
04
Relevant glossary terms
05
Verified bibliography
Reference 1
Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M
Nature · 2001-05-31 · Journal Article
currentReference 2
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brézillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M
The Journal of biological chemistry · 2001-07-16 · Journal Article
currentReference 3
AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1.Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC
The Journal of biological chemistry · 2001-05-31 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Ohtaki T et al. 2001 | Study models reported: in vitro; in vivo (subject not stated) · from the abstract |
| Kotani M et al. 2001 | Study models reported: in vitro; animal (rat) · from the abstract |
| Muir AI et al. 2001 | Study models reported: in vitro · from the abstract |
06
Related Purely Peptides research articles
No existing Research Article is mapped to this class seed record.
07