same family

GLP-1(7-36) amide vs GLP-1(7-37)

These are distinct GLP-1 processing forms: one ends in an amidated arginine, while the other retains an additional C-terminal glycine.

Published: 2026-10-03Library record comparison: 2026-10-03

Identity side by side

Recorded molecular identities of GLP-1(7-36) amide and GLP-1(7-37)
Recorded field	GLP-1(7-36) amide	GLP-1(7-37)
Canonical name	Glucagon-like peptide-1 (7-36) amide	Glucagon-like peptide-1 (7-37)
Aliases	GLP-1(7-36)amide; GLP-1 7-36 amide; Insulinotropin	GLP-1 7-37; GLP-I(7-37)
Development codes	not recorded	not recorded
CAS	107444-51-9	not recorded
UNII	0JS9125PIZ	not recorded
PubChem CID	16133831	not recorded
Molecular formula	C149H226N40O45	C151H228N40O47
Molecular weight (Da)	3297.7	3355.7
Sequence length (residues)	30	31
Terminal modifications	C-terminal amide	Free C-terminal carboxyl
Structural modifications	not recorded	not recorded

GLP-1(7-36) amide: nomenclature notes

'GLP-1(7-36)' without an amidation designation is not sufficiently specified. This entry is the AMIDATED form; GLP-1(7-37) is a separate molecule with an additional terminal glycine and a free carboxyl, recorded separately in this library. Amidation is not a counterion difference. GLP-1(1-37) is the N-terminally extended proform and is not this hormone; describing it as an inactive precursor is appropriate only in the sense that it is not the conventional mature insulinotropic form.

GLP-1(7-37): nomenclature notes

This is the reference scaffold for the acylated GLP-1 analogs in this library, because they retain the C-terminal glycine. 'Both are GLP-1 analogs' is not sufficient for this corpus: which native form an analog is built on determines whether its modification table is right. Neither CAS nor UNII is recorded here — an unsalted identity was not reconciled to an authoritative record, and an acetate-specific identifier is not an acceptable substitute.

Residue sequence comparison

Positions are numbered from each stored sequence’s first residue. Highlighted cells differ or extend beyond the other chain; a dash indicates no aligned residue. One-letter notation does not encode terminal groups or stereochemistry. Read the recorded notes below.

Aligned one-letter residue sequences
GLP-1(7-36) amide	1H	2A	3E	4G	5T	6F	7T	8S	9D	10V	11S	12S	13Y	14L	15E	16G	17Q	18A	19A	20K	21E	22F	23I	24A	25W	26L	27V	28K	29G	30R	·—
GLP-1(7-37)	1H	2A	3E	4G	5T	6F	7T	8S	9D	10V	11S	12S	13Y	14L	15E	16G	17Q	18A	19A	20K	21E	22F	23I	24A	25W	26L	27V	28K	29G	30R	31G

Differences in text

GLP-1(7-36) amide: no aligned residue; GLP-1(7-37): residue 31 = G.

GLP-1(7-36) amide

Terminal modifications: C-terminal amide
Structural modifications: not recorded
Sequence notes: Thirty residues ending in an amidated arginine. The conventional 7-36 numbering is retained rather than renumbering the mature N-terminal histidine as residue 1 — every modification table for every GLP-1 analog in this library uses that convention, and silently renumbering produces wrong records.

GLP-1(7-37)

Terminal modifications: Free C-terminal carboxyl
Structural modifications: not recorded
Sequence notes: Thirty-one residues ending in glycine with a FREE C-terminal carboxyl. Distinct from both the amidated 30-residue form and from GLP-1(1-37). Conventional 7-37 numbering retained: Ala8 is the second residue of the mature peptide, Lys26 the twentieth, Lys34 the twenty-eighth. Mixing numbering systems silently produces incorrect modification records for every analog derived from this scaffold.