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Purely Peptides
Research Catalog

fragment of

Kisspeptin-10 vs Kisspeptin-14

Kisspeptin-10 matches the final ten residues of kisspeptin-14. This sequence relationship does not establish a serial processing pathway.

Published: 2026-10-03Library record comparison: 2026-10-03

01

Identity side by side

Recorded molecular identities of Kisspeptin-10 and Kisspeptin-14
Recorded fieldKisspeptin-10Kisspeptin-14
Canonical nameKisspeptin-10Kisspeptin-14
AliasesKP-10; Metastin (45-54); Human metastin 45-54KP-14; Metastin(41-54)
Development codesnot recordednot recorded
CAS374675-21-5374675-19-1
UNIIFS1N52VS3Snot recorded
PubChem CID25240297171916517
Molecular formulaC63H83N17O14C82H112N22O21
Molecular weight (Da)1302.41741.9
Sequence length (residues)1014
Terminal modificationsC-terminal amidationC-terminal amide
Structural modificationsnot recordednot recorded

Kisspeptin-10: nomenclature notes

KP-10 and metastin (45-54) identify the amidated ten-residue C-terminal fragment of the human KISS1-derived peptide sequence.

Kisspeptin-14: nomenclature notes

A fourteen-residue kisspeptin was isolated from human placenta alongside the 54- and 13-residue forms. KP-14 contains the kisspeptin-10 sequence at its C terminus. Removing its initial aspartate gives the 13-residue sequence; removing DLPN gives the 10-residue sequence. These are different molecular forms even where receptor responses are similar.

02

Residue sequence comparison

Positions are numbered from each stored sequence’s first residue. Highlighted cells differ or extend beyond the other chain; a dash indicates no aligned residue. One-letter notation does not encode terminal groups or stereochemistry. Read the recorded notes below.

Aligned one-letter residue sequences
Kisspeptin-10·—·—·—·—1Y2N3W4N5S6F7G8L9R10F
Kisspeptin-141D2L3P4N5Y6N7W8N9S10F11G12L13R14F

Differences in text

  • Kisspeptin-10: no aligned residue; Kisspeptin-14: residue 1 = D.
  • Kisspeptin-10: no aligned residue; Kisspeptin-14: residue 2 = L.
  • Kisspeptin-10: no aligned residue; Kisspeptin-14: residue 3 = P.
  • Kisspeptin-10: no aligned residue; Kisspeptin-14: residue 4 = N.

Kisspeptin-10

Terminal modifications
C-terminal amidation
Structural modifications
not recorded
Stored three-letter notation
Tyr · Asn · Trp · Asn · Ser · Phe · Gly · Leu · Arg · Phe-NH2
Sequence notes
The PubChem molecular record represents the C-terminal phenylalanine as an amide.

Kisspeptin-14

Terminal modifications
C-terminal amide
Structural modifications
not recorded
Sequence notes
Fourteen residues with a C-terminal amide, free N-terminus, no cyclization or nonstandard residue. The final ten residues are the entire kisspeptin-10 sequence; the distinguishing part is the N-terminal DLPN.

03

Recorded mechanisms

These lists show the links recorded in each monograph. An unlisted link does not establish its absence from the molecule’s biology.

Shared recorded links

Recorded only for Kisspeptin-10

not recorded

Recorded only for Kisspeptin-14

not recorded

04

Recorded compound classes

Shared recorded links

Recorded only for Kisspeptin-10

not recorded

Recorded only for Kisspeptin-14

not recorded

05

References for the relationship

  1. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.

    Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brézillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M

    The Journal of biological chemistry · 2001-07-16 · Journal Article

    current
    PMID 11457843DOI 10.1074/jbc.M104847200Kisspeptin-10Kisspeptin-14KISS1R

06

Read the full monographs

Kisspeptin-10 →Kisspeptin-14 →