Compound monograph
Angiotensin-(1-7)
Talfirastide, also called Angiotensin-(1-7), is a linear all-L heptapeptide with sequence Asp–Arg–Val–Tyr–Ile–His–Pro, an uncapped amino terminus and a C-terminal carboxyl group.
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Identity & nomenclature
Talfirastide, also called Angiotensin-(1-7), is a linear all-L heptapeptide with sequence Asp–Arg–Val–Tyr–Ile–His–Pro, an uncapped amino terminus and a C-terminal carboxyl group.
Talfirastide and Angiotensin-(1-7) denote the same defined peptide parent. Fragment notation does not specify a preparation’s counterion or hydration state.
Canonical name: Talfirastide.
Declared aliases and development codes: Angiotensin (1-7), Ang-(1-7), Talfirastidum, Talfirastida, TXA127.
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Molecular properties
| Molecular formula | C41H62N12O11 |
|---|---|
| Molecular mass | 899.02 Da |
| CAS Registry Number | 51833-78-4 |
| PubChem CID | 123805 |
| UNII | IJ3FUK8MOF |
| One-letter sequence | DRVYIHP |
| Three-letter sequence | Asp–Arg–Val–Tyr–Ile–His–Pro |
| Terminal groups | Free N-terminal amino group; Free C-terminal carboxyl group |
Seven standard proteinogenic residues, all L; Ile denotes the natural L-isoleucine stereoisomer. The sequence begins at Asp and ends at Pro.
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Structural characteristics
The defined parent contains six conventional peptide bonds and no covalent macrocycle or disulfide bridge.
Terminal features: Free N-terminal amino group, Free C-terminal carboxyl group.
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Molecular targets & mechanisms
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Analytical considerations
No compound-specific analytical note is recorded for this compound; identifier and bibliography verification remain available below.
What the studies reported
Each finding describes one cited study in its stated model. These observations are specific to that study and do not establish effects in other settings.
Cell and tissue studies
Normal human astrocytes (NHA) and immortalized human cerebral microvascular endothelial hCMEC/D3 cells
Alabsi et al. found no statistically significant difference in relative cell viability between Ang-(1–7)-exposed cultures and controls in normal human astrocytes (NHA) and human cerebral microvascular endothelial hCMEC/D3 cells across the tested concentration range (p values >0.05).
Reference [1]Human RPMI2650 nasal anaplastic squamous-cell carcinoma, A549 alveolar adenocarcinoma, and H441 lung adenocarcinoma cells
Alabsi et al. found no statistically significant difference in relative cell viability between Ang-(1–7)-exposed cultures and controls in human RPMI2650 nasal anaplastic squamous-cell carcinoma, A549 alveolar adenocarcinoma, and H441 lung adenocarcinoma cells across the tested concentration range (p values >0.05).
Reference [1]
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Verified bibliography
Cited studies by type
The 2 papers this record cites, counted by the kind of work each reports. A count is the size of this record's selection, not of the research that exists, and says nothing about results, safety, effectiveness or approval.
A paper can report more than one kind of work. Each count opens those papers in the bibliography. Compare every record on the Evidence Map.
Reference 1
Synthesis, Physicochemical Characterization, In Vitro 2D/3D Human Cell Culture, and In Vitro Aerosol Dispersion Performance of Advanced Spray Dried and Co-Spray Dried Angiotensin (1-7) Peptide and PNA5 with Trehalose as Microparticles/Nanoparticles for Targeted Respiratory Delivery as Dry Powder Inhalers.Alabsi W, Acosta MF, Al-Obeidi FA, Hay M, Polt R, Mansour HM
Pharmaceutics · 2021-08-17 · Journal Article
currentReference 2
Study of angiotensin-(1-7) vasoactive peptide and its beta-cyclodextrin inclusion complexes: complete sequence-specific NMR assignments and structural studies.Lula I, Denadai AL, Resende JM, de Sousa FB, de Lima GF, Pilo-Veloso D, Heine T, Duarte HA, Santos RA, Sinisterra RD
Peptides · 2007-08-19 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Alabsi W et al. 2021 | Study models reported: in vitro · from the abstract |
| Lula I et al. 2007 | Chemical, structural or analytical study; no biological model reported |
Record history
Published 2026-09-29.
No changes to this record's content have been recorded since publication.
Each entry names the parts of this record that changed on that date. Changes to links between records and to catalogue links are not listed. This history covers the tracked record fields; study findings are not listed here.
Cite this record: Purely Peptides Research Library. Angiotensin-(1-7). Published 2026-09-29. https://purelypeptides.org/research/compounds/angiotensin-1-7/
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Methodology & citation verification
Reference identity is checked against official PubMed metadata. Local deterministic receipts bind each normalized title and canonical metadata record to its verification date. Scientific values remain absent when an authoritative source has not been verified.
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