Compound monograph
Angiotensin-(1-7)
Talfirastide, also called Angiotensin-(1-7), is a linear all-L heptapeptide with sequence Asp–Arg–Val–Tyr–Ile–His–Pro, an uncapped amino terminus and a C-terminal carboxyl group.
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Identity & nomenclature
Talfirastide, also called Angiotensin-(1-7), is a linear all-L heptapeptide with sequence Asp–Arg–Val–Tyr–Ile–His–Pro, an uncapped amino terminus and a C-terminal carboxyl group.
Talfirastide and Angiotensin-(1-7) denote the same defined peptide parent. Fragment notation does not specify a preparation’s counterion or hydration state.
Canonical name: Talfirastide.
Declared aliases and development codes: Angiotensin (1-7), Ang-(1-7), Talfirastidum, Talfirastida, TXA127.
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Molecular properties
| Molecular formula | C41H62N12O11 |
|---|---|
| Molecular mass | 899.02 Da |
| CAS Registry Number | 51833-78-4 |
| PubChem CID | 123805 |
| UNII | IJ3FUK8MOF |
| One-letter sequence | DRVYIHP |
| Three-letter sequence | Asp–Arg–Val–Tyr–Ile–His–Pro |
Seven standard proteinogenic residues, all L; Ile denotes the natural L-isoleucine stereoisomer. The sequence begins at Asp and ends at Pro.
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Structural characteristics
The defined parent contains six conventional peptide bonds and no covalent macrocycle or disulfide bridge.
Terminal features: Free N-terminal amino group, Free C-terminal carboxyl group.
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Molecular targets & mechanisms
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Analytical considerations
No compound-specific analytical note is recorded for this compound; identifier and bibliography verification remain available below.
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Verified bibliography
- Synthesis, Physicochemical Characterization, In Vitro 2D/3D Human Cell Culture, and In Vitro Aerosol Dispersion Performance of Advanced Spray Dried and Co-Spray Dried Angiotensin (1-7) Peptide and PNA5 with Trehalose as Microparticles/Nanoparticles for Targeted Respiratory Delivery as Dry Powder Inhalers.
Alabsi W, Acosta MF, Al-Obeidi FA, Hay M, Polt R, Mansour HM
Pharmaceutics · 2021-08-17 · Journal Article
current - Study of angiotensin-(1-7) vasoactive peptide and its beta-cyclodextrin inclusion complexes: complete sequence-specific NMR assignments and structural studies.
Lula I, Denadai AL, Resende JM, de Sousa FB, de Lima GF, Pilo-Veloso D, Heine T, Duarte HA, Santos RA, Sinisterra RD
Peptides · 2007-08-19 · Journal Article
current
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Methodology & citation verification
Reference identity is checked against official PubMed metadata. Local deterministic receipts bind each normalized title and canonical metadata record to its verification date. Scientific values remain absent when an authoritative source has not been verified.
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