Compound monograph
Goserelin
Goserelin is a synthetic peptide parent containing an L-pyroglutamyl first unit, an O-tert-butyl-D-seryl unit at position 6 and a carbamoylhydrazide terminus. This record excludes counterions and water components.
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Identity & nomenclature
Goserelin is a synthetic peptide parent containing an L-pyroglutamyl first unit, an O-tert-butyl-D-seryl unit at position 6 and a carbamoylhydrazide terminus. This record excludes counterions and water components.
The parent and acetate-containing material have distinct composition boundaries. Nine conventional amino-acid-derived units plus a semicarbazide end and a ten-position notation including azaglycine describe the stated connectivity; this record stores the end group separately from the residue chain.
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Molecular properties
| Molecular formula | C59H84N18O14 |
|---|---|
| Molecular mass | 1269.433 Da |
| PubChem CID | 5311128 |
| UNII | 0F65R8P09N |
| Three-letter sequence | pGlu–His–Trp–Ser–Tyr–D-Ser(O-tBu)–Leu–Arg–Pro |
| Terminal groups | N-terminal pyroglutamate; C-terminal aza-glycinamide at Pro9 |
pGlu is one L-pyroglutamyl (5-oxo-L-prolyl) unit. D-Ser(O-tBu) is one O-tert-butyl-D-seryl unit, with the ether on side-chain oxygen. Chiral positions 1–5 and 7–9 are L; position 6 is D. The stored chain contains nine amino-acid-derived units; the aza-glycinamide end is declared as terminal chemistry. Its full connectivity is Pro9–C(=O)–NH–NH–C(=O)–NH2. No one-letter string is supplied.
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Structural characteristics
Dutta et al. reported synthesis of substituted aza analogues. Sanz-Nebot et al. reported chromatographic separation and mass-spectrometric identification of a goserelin synthesis mixture. The inspected abstracts do not establish a complete stereochemical audit of every preparation. The pyroglutamyl ring lies within residue 1; there is no inter-residue ring closure.
- O-tert-butyl ether on D-Ser6
Terminal features: N-terminal pyroglutamate, C-terminal aza-glycinamide at Pro9.
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Molecular targets & mechanisms
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Analytical considerations
The formula and 1269.433 Da average mass follow the defined parent structure using CIAAW 2024 abridged atomic weights. The terminal carbamoylhydrazide is neither a simple proline amide nor a proline ethylamide. A fixed acetate or hydrate composition is not assigned to the parent.
What the studies reported
No verified findings are published for this record under Content Policy v1.
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Verified bibliography
Cited studies by type
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Reference 1
Synthesis and biological activity of highly active alpha-aza analogues of luliberin.Dutta AS, Furr BJ, Giles MB, Valcaccia B
Journal of medicinal chemistry · 1978-10 · Journal Article
currentReference 2
Liquid chromatography-electrospray mass spectrometry of multicomponent peptide mixtures. Characterization of a mixture from the synthesis of the hormone goserelin.Sanz-Nebot V, Benavente F, Castillo A, Barbosa J
Journal of chromatography. A · 2000-08-11 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Dutta AS et al. 1978 | Study models reported: animal (rat) · from the abstract |
| Sanz-Nebot V et al. 2000 | Chemical, structural or analytical study; no biological model reported |
Record history
Published 2026-10-20.
No changes to this record's content have been recorded since publication.
Each entry names the parts of this record that changed on that date. Changes to links between records and to catalogue links are not listed. This history covers the tracked record fields; study findings are not listed here.
Cite this record: Purely Peptides Research Library. Goserelin. Published 2026-10-20. https://purelypeptides.org/research/compounds/goserelin/
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Methodology & citation verification
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