Compound monograph
Larazotide
Larazotide is a linear octapeptide with free N and C termini. This record describes the defined parent peptide composition separately from counterion-containing and hydrated preparations.
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Identity & nomenclature
Larazotide is a linear octapeptide with free N and C termini. This record describes the defined parent peptide composition separately from counterion-containing and hydrated preparations.
Larazotidum and larazotida are WHO language forms of the parent name. WHO Recommended INN List 61 defines the parent; US9051349B2 describes synthesis and distinguishes salt and hydrated preparations. Acetate-qualified names and shared development codes are not admitted as exact parent aliases.
Declared aliases and development codes: larazotidum, larazotida.
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Molecular properties
| Molecular formula | C32H55N9O10 |
|---|---|
| Molecular mass | 725.845 Da |
| CAS Registry Number | 258818-34-7 |
| PubChem CID | 9810532 |
| UNII | ZN3R5560ZV |
| One-letter sequence | GGVLVQPG |
| Three-letter sequence | Gly–Gly–Val–Leu–Val–Gln–Pro–Gly |
| Terminal groups | Free N-terminus; Free C-terminal carboxyl |
Eight standard residues numbered from Gly1. All chiral residues are L; glycine is achiral. The chain has seven ordinary peptide bonds and free termini. No counterion or hydration component is included.
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Structural characteristics
The defined parent is a linear octapeptide with free amino and carboxyl termini. The patent synthesis and Di Micco et al. synthesis and supplementary analytical material support the covalent parent. A separate January 2021 synthesis account gives conflicting Gly-Wang and Ile-Wang resin descriptions; its actual material remains unresolved and is not used to redefine this parent.
Terminal features: Free N-terminus, Free C-terminal carboxyl.
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Molecular targets & mechanisms
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Analytical considerations
The formula matches WHO Recommended INN List 61; the 725.845 Da average mass is calculated using CIAAW 2024 abridged atomic weights. PubChem reports 725.8 at one-decimal precision. GSRS estimates 726.0 under an unestablished mass convention; that number is non-defining. Di Micco et al. report an ESI [M+H]+ value of 726.4125, compared with the calculated 726.41446547480; analytical acceptance tolerance is not established. Ion m/z, neutral monoisotopic mass and average molecular mass are distinct.
What the studies reported
No verified findings are published for this record under Content Policy v1.
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Verified bibliography
Cited studies by type
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Reference 1
Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation.Di Micco S, Musella S, Sala M, Scala MC, Andrei G, Snoeck R, Bifulco G, Campiglia P, Fasano A
International journal of molecular sciences · 2021-08-30 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Di Micco S et al. 2021 | Study models reported: in vitro · from the abstract |
Record history
Published 2026-10-20.
No changes to this record's content have been recorded since publication.
Each entry names the parts of this record that changed on that date. Changes to links between records and to catalogue links are not listed. This history covers the tracked record fields; study findings are not listed here.
Cite this record: Purely Peptides Research Library. Larazotide. Published 2026-10-20. https://purelypeptides.org/research/compounds/larazotide/
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Methodology & citation verification
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