Compound monograph
Noopept (Omberacetam)
Omberacetam is N-phenylacetyl-L-prolylglycine ethyl ester, a terminally modified dipeptide. This record describes the neutral parent.
01
Identity & nomenclature
Omberacetam is N-phenylacetyl-L-prolylglycine ethyl ester, a terminally modified dipeptide. This record describes the neutral parent.
Omberacetam is the nonproprietary name. The chemical alias identifies the terminally modified L-Pro–Gly entity; descriptions without explicit stereochemistry do not establish the same sample configuration. Salts, solvates and other solid forms require separate specification.
Canonical name: Omberacetam.
Declared aliases and development codes: N-phenylacetyl-L-prolylglycine ethyl ester, omberacetamum, ombéracétam, GVS-111.
02
Molecular properties
| Molecular formula | C17H22N2O4 |
|---|---|
| Molecular mass | 318.373 Da |
| CAS Registry Number | 157115-85-0 |
| PubChem CID | 180496 |
| UNII | 4QBJ98683M |
| One-letter sequence | PG |
| Three-letter sequence | Pro–Gly |
| Terminal groups | N-terminal phenylacetylation at Pro1; C-terminal ethyl ester at Gly2 |
The chain is L-Pro1–Gly2. Glycine is achiral. PG denotes only the residue chain; the N-terminal phenylacetyl group and C-terminal ethyl ester are declared separately and are necessary to identify the complete molecule. The proline ring is intrinsic to its residue.
03
Structural characteristics
Araj et al. reported NMR, diffraction and other physicochemical characterization. The accessible structural evidence is partial: the full experimental article and supplementary crystallographic detail were not audited in the source dossier. The phenylacetyl cap is attached to proline nitrogen; the ethyl ester is at glycine carboxyl.
Terminal features: N-terminal phenylacetylation at Pro1, C-terminal ethyl ester at Gly2.
04
Molecular targets & mechanisms
05
Analytical considerations
The recorded 318.373 Da is the CIAAW 2024 average mass calculated from C17H22N2O4. Jia et al. (PMID 21986202; DOI 10.1016/j.jmb.2011.10.005) report MW 319 in their materials section without specifying its mass convention or ion/species basis. That divergent statement remains unreconciled and is non-defining for this formula-derived field; agreement is not established, and no protonated-ion assignment is inferred. Formula agreement alone does not establish sample enantiomeric purity or equivalence of solid forms.
What the studies reported
No verified findings are published for this record under Content Policy v1.
06
Verified bibliography
Cited studies by type
The one paper this record cites, counted by the kind of work each reports. A count is the size of this record's selection, not of the research that exists, and says nothing about results, safety, effectiveness or approval.
A paper can report more than one kind of work. Each count opens those papers in the bibliography. Compare every record on the Evidence Map.
Reference 1
Physicochemical and structural analysis of N-phenylacetyl-L-prolylglycine ethyl ester (Noopept) - An active pharmaceutical ingredient with nootropic activity.Araj SK, Szeleszczuk Ł, Gubica T, Zielińska-Pisklak M, Bethanis K, Christoforides E, Dudek MK, Pisklak DM
Journal of pharmaceutical and biomedical analysis · 2024-09-16 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Araj SK et al. 2024 | Chemical, structural or analytical study; no biological model reported |
Record history
Published 2026-10-20.
- : Sequence and structure, Analytical notes
Each entry names the parts of this record that changed on that date. Changes to links between records and to catalogue links are not listed. This history covers the tracked record fields; study findings are not listed here.
Cite this record: Purely Peptides Research Library. Noopept (Omberacetam). Published 2026-10-20; updated 2026-10-20. https://purelypeptides.org/research/compounds/noopept/
10
Methodology & citation verification
Reference identity is checked against official PubMed metadata. Local deterministic receipts bind each normalized title and canonical metadata record to its verification date. Scientific values remain absent when an authoritative source has not been verified.
Read the full methodology →