Compound monograph
Plecanatide
Plecanatide is a synthetic 16-residue peptide with free termini and two intramolecular disulfide bridges.
01
Identity & nomenclature
Plecanatide is a synthetic 16-residue peptide with free termini and two intramolecular disulfide bridges.
This record describes the covalent parent without counterion or hydration components.
Declared aliases and development codes: plecanatidum, plécanatide, plecanatida.
02
Molecular properties
| Molecular formula | C65H104N18O26S4 |
|---|---|
| Molecular mass | 1681.887 Da |
| CAS Registry Number | 467426-54-6 |
| PubChem CID | 70693500 |
| UNII | 7IK8Z952OK |
| One-letter sequence | NDECELCVNVACTGCL |
| Three-letter sequence | Asn–Asp–Glu–Cys–Glu–Leu–Cys–Val–Asn–Val–Ala–Cys–Thr–Gly–Cys–Leu |
| Terminal groups | Free N-terminus; Free C-terminal carboxyl |
Positions count the mature 16-residue chain, Asn1 through Leu16. All chiral residues are L and glycine is achiral. The free amino and carboxyl termini remain open. Disulfides join Cys4-Cys12 and Cys7-Cys15. Li et al. form Cys7-Cys15 first; Kremsmayr et al. use the opposite folding order and report a reverse-order topoisomer. Exact final conformer equivalence is unestablished; the pairings do not specify a unique three-dimensional conformer.
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Structural characteristics
Positions count the mature 16-residue chain, Asn1 through Leu16. All chiral residues are L and glycine is achiral. The free amino and carboxyl termini remain open. Disulfides join Cys4-Cys12 and Cys7-Cys15. Li et al. form Cys7-Cys15 first; Kremsmayr et al. use the opposite folding order and report a reverse-order topoisomer. Exact final conformer equivalence is unestablished; the pairings do not specify a unique three-dimensional conformer.
- Cys4-Cys12 intramolecular disulfide
- Cys7-Cys15 intramolecular disulfide
Ring closures: covalent bonds between residues, by position counted from the first residue of the chain.
- Disulfide Cys4–Cys12: thiol sulfur (Sγ) to thiol sulfur (Sγ). Source: PMID 32275447.
- Disulfide Cys7–Cys15: thiol sulfur (Sγ) to thiol sulfur (Sγ). Source: PMID 32275447.
Terminal features: Free N-terminus, Free C-terminal carboxyl.
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Molecular targets & mechanisms
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Analytical considerations
The molecular formula describes the parent; the average mass is calculated using CIAAW 2024 abridged atomic weights. PubChem reports 1681.9 Da (-0.013 Da, -7.729 ppm). FDA prints 1682 Daltons (-0.113 Da, -67.182 ppm) under an unestablished mass convention. Li et al. report calculated [M+H]+ 1681.6324 and found 1681.6325; these are ion values, separate from average molecular mass.
What the studies reported
No verified findings are published for this record under Content Policy v1.
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Verified bibliography
Cited studies by type
The 2 papers this record cites, counted by the kind of work each reports. A count is the size of this record's selection, not of the research that exists, and says nothing about results, safety, effectiveness or approval.
A paper can report more than one kind of work. Each count opens those papers in the bibliography. Compare every record on the Evidence Map.
Reference 1
Liquid-Phase Total Synthesis of Plecanatide Aided by Diphenylphosphinyloxyl Diphenyl Ketone (DDK) Derivatives.Li H, Chao J, Zhang Z, Tian G, Li J, Chang N, Qin C
Organic letters · 2020-04-10 · Journal Article
currentReference 2
On the Utility of Chemical Strategies to Improve Peptide Gut Stability.Kremsmayr T, Aljnabi A, Blanco-Canosa JB, Tran HNT, Emidio NB, Muttenthaler M
Journal of medicinal chemistry · 2022-04-14 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Li H et al. 2020 | Chemical, structural or analytical study; no biological model reported |
| Kremsmayr T et al. 2022 | Chemical, structural or analytical study; no biological model reported |
Record history
Published 2026-10-21.
No changes to this record's content have been recorded since publication.
Each entry names the parts of this record that changed on that date. Changes to links between records and to catalogue links are not listed. This history covers the tracked record fields; study findings are not listed here.
Cite this record: Purely Peptides Research Library. Plecanatide. Published 2026-10-21. https://purelypeptides.org/research/compounds/plecanatide/
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Methodology & citation verification
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