Compound monograph
Arginine vasopressin
Arginine vasopressin is a nine-residue peptide with a free N-terminus, a C-terminal glycinamide and a Cys1-Cys6 disulfide.
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Identity & nomenclature
Arginine vasopressin is a nine-residue peptide with a free N-terminus, a C-terminal glycinamide and a Cys1-Cys6 disulfide.
This record identifies the mature arginine-containing parent. The bare name vasopressin is context-dependent and does not establish universal equivalence of historical materials, formulations, precursors or registry entries. Salt and hydrate stoichiometry are not established. PubChem CID 644077 denotes the fully specified structure; CID 8230 is not substituted for it.
Canonical name: Argipressin.
Declared aliases and development codes: Arginine-vasopressin, AVP.
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Molecular properties
| Molecular formula | C46H65N15O12S2 |
|---|---|
| Molecular mass | 1084.239 Da |
| CAS Registry Number | 113-79-1 |
| PubChem CID | 644077 |
| UNII | Y4907O6MFD |
| One-letter sequence | CYFQNCPRG |
| Three-letter sequence | Cys–Tyr–Phe–Gln–Asn–Cys–Pro–Arg–Gly |
| Terminal groups | Free N-terminus; C-terminal amide at Gly9 |
Nine chain residues, numbered from Cys1. All eight chiral residues are L; Gly9 is achiral. The terminal amide and disulfide are represented separately.
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Structural characteristics
The chain contains eight L-configured residues and achiral Gly9. The intramolecular disulfide connects the cysteine side-chain sulfurs; the backbone retains distinct N and C ends.
- Cys1-Cys6 intramolecular disulfide
Ring closures: covalent bonds between residues, by position counted from the first residue of the chain.
- Disulfide Cys1–Cys6: thiol sulfur (Sγ) to thiol sulfur (Sγ). Source: PMID 24641490.
Terminal features: Free N-terminus, C-terminal amide at Gly9.
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Molecular targets & mechanisms
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Analytical considerations
The neutral oxidized parent formula is derived from the independently established chain, terminal amide and disulfide. The average mass is 1084.239 Da using CIAAW 2024 abridged atomic weights. PubChem and the GSRS linked chemical definition agree with C46H65N15O12S2. The GSRS primary record instead reports non-defining estimated C46H63O12N14S2: the derived formula differs by +H2N. That registry attribute calculates to 1068.216 Da with the same table. Its non-defining estimated mass is 1090 Da, a derived-minus-reported difference of -5.761 Da (-5285.3211 ppm); its isotope-weight convention is not established. The registry chemical definition and non-defining attribute remain divergent; no cause or correction is asserted.
What the studies reported
No verified findings are published for this record under Content Policy v1.
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Verified bibliography
Cited studies by type
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Reference 1
Immobilized N-chlorosuccinimide as a friendly peptide disulfide-forming reagent.Postma TM, Albericio F
ACS combinatorial science · 2014-03-31 · Journal Article
currentReference 2
Arginine-, D-arginine-vasopressin, and their inverso analogues in micellar and liposomic models of cell membrane: CD, NMR, and molecular dynamics studies.Lubecka EA, Sikorska E, Sobolewski D, Prahl A, Slaninová J, Ciarkowski J
European biophysics journal : EBJ · 2015-08-20 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Postma TM et al. 2014 | Chemical, structural or analytical study; no biological model reported |
| Lubecka EA et al. 2015 | Study models reported: in vitro · from the abstract |
Record history
Published 2026-10-22.
No changes to this record's content have been recorded since publication.
Each entry names the parts of this record that changed on that date. Changes to links between records and to catalogue links are not listed. This history covers the tracked record fields; study findings are not listed here.
Cite this record: Purely Peptides Research Library. Arginine vasopressin. Published 2026-10-22. https://purelypeptides.org/research/compounds/vasopressin/
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Methodology & citation verification
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