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Research Catalog

Compound monograph

Cetrorelix

Cetrorelix is a synthetic linear decapeptide with defined D/L configuration and nonstandard residues, an acetylated N terminus and an amidated C terminus. This record describes the parent without counterion.

Published: 2026-10-20Literature/identifier verification: 2026-10-20
Also known ascetrorelixum
GnRH peptide analogs

01

Identity & nomenclature

Cetrorelix is a synthetic linear decapeptide with defined D/L configuration and nonstandard residues, an acetylated N terminus and an amidated C terminus. This record describes the parent without counterion.

Cetrorelixum is the issued Latin name. Acetate-qualified names describe separately specified material and are excluded from the parent aliases and identifiers. No development code is admitted from the source dossier.

Declared aliases and development codes: cetrorelixum.

02

Molecular properties

Molecular formulaC70H92ClN17O14
Molecular mass1431.061 Da
CAS Registry Number120287-85-6
PubChem CID25074887
UNIIOON1HFZ4BA
Three-letter sequenceD-Nal(2)–D-Phe(4-Cl)–D-Pal(3)–Ser–Tyr–D-Cit–Leu–Arg–Pro–D-Ala
Terminal groupsN-terminal acetylation; C-terminal amide

Ten residues numbered from the first D residue. D-Nal(2) is D-3-(naphthalen-2-yl)alanine; D-Phe(4-Cl) is D-4-chlorophenylalanine; D-Pal(3) is D-3-(pyridin-3-yl)alanine. D-Cit is D-citrulline, or N5-carbamoyl-D-ornithine. Positions 1, 2, 3, 6 and 10 are D; positions 4, 5, 7, 8 and 9 are L. Every nonstandard token denotes one residue. No one-letter string is supplied.

03

Structural characteristics

Müller et al. reported MS and NMR structural characterization; Aluri et al. reported synthesis and differentiation of epimeric impurities in acetate material. Their accessible abstracts are partial structural evidence and do not establish an independent experimental configuration measurement at every residue. The stored chain is linear, with no inter-residue ring closure.

  • D configuration at positions 1, 2, 3, 6 and 10

Terminal features: N-terminal acetylation, C-terminal amide.

04

Molecular targets & mechanisms

05

Analytical considerations

The formula and 1431.061 Da average mass are calculated for the neutral parent using CIAAW 2024 abridged atomic weights. PubChem displays 1431.0; the 0.061 Da numerical discrepancy is retained and that value is not substituted for the defined calculation. Acetate components and impurity modifications are excluded.

What the studies reported

No verified findings are published for this record under Content Policy v1.

06

Verified bibliography

Cited studies by type

The 2 papers this record cites, counted by the kind of work each reports. A count is the size of this record's selection, not of the research that exists, and says nothing about results, safety, effectiveness or approval.

A paper can report more than one kind of work. Each count opens those papers in the bibliography. Compare every record on the Evidence Map.

  1. Reference 1

    Structural investigation of Cetrorelix, a new potent and long-acting LH-RH antagonist.

    Müller A, Busker E, Engel J, Kutscher B, Bernd M, Schally AV

    International journal of peptide and protein research · 1994-03 · Journal Article

    current
    PMID 8005749DOI 10.1111/j.1399-3011.1994.tb00389.xCetrorelix

  2. Reference 2

    Synthesis of Diastereomerically Pure Cetrorelix Acetate by Using Fmoc Solid-Phase Peptide Synthesis (SPPS) Strategy: A Commercially Viable Approach.

    Aluri K, Basavoju S, Rangisetty JB, Pullagurla MR, Pitta BR

    Journal of peptide science : an official publication of the European Peptide Society · 2025-06 · Journal Article

    current
    PMID 40386934DOI 10.1002/psc.70030Cetrorelix

Study models of these references

What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.

ReferenceStudy models
Müller A et al. 1994Chemical, structural or analytical study; no biological model reported
Aluri K et al. 2025Chemical, structural or analytical study; no biological model reported

Record history

Published 2026-10-20.

No changes to this record's content have been recorded since publication.

Each entry names the parts of this record that changed on that date. Changes to links between records and to catalogue links are not listed. This history covers the tracked record fields; study findings are not listed here.

Cite this record: Purely Peptides Research Library. Cetrorelix. Published 2026-10-20. https://purelypeptides.org/research/compounds/cetrorelix/

10

Methodology & citation verification

Reference identity is checked against official PubMed metadata. Local deterministic receipts bind each normalized title and canonical metadata record to its verification date. Scientific values remain absent when an authoritative source has not been verified.

Read the full methodology →