Compound monograph
BPC-157
BPC-157 is a synthetic fifteen-residue peptide corresponding to a partial sequence of body protection compound, a protein reported to have been isolated from human gastric juice.
01
Identity & nomenclature
BPC-157 is a synthetic fifteen-residue peptide corresponding to a partial sequence of body protection compound, a protein reported to have been isolated from human gastric juice.
BPC-157 is described in the literature as a partial sequence of body protection compound, a protein reported to have been isolated from human gastric juice. PubChem lists Bepecin and BPC 15 as synonyms. It has no approved regulatory status in any jurisdiction.
Declared aliases and development codes: Bepecin, BPC 15.
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Molecular properties
| Molecular formula | C62H98N16O22 |
|---|---|
| Molecular mass | 1419.5 Da |
| CAS Registry Number | 137525-51-0 |
| PubChem CID | 9941957 |
| UNII | 8ED8NXK95P |
| One-letter sequence | GEPPPGKPADDAGLV |
| Three-letter sequence | Gly–Glu–Pro–Pro–Pro–Gly–Lys–Pro–Ala–Asp–Asp–Ala–Gly–Leu–Val |
Sequence derived from the systematic name in the PubChem molecular record.
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Structural characteristics
The peptide contains three consecutive proline residues at positions 3 to 5 and a fourth proline at position 8. It carries no reported terminal modification in the PubChem molecular record.
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Molecular targets & mechanisms
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Analytical considerations
The sequence contains no aromatic residues, so UV detection at 280 nm gives no useful chromophore response. Identity confirmation therefore relies on mass and sequence-level methods rather than UV absorbance, and the proline-rich backbone should be accounted for in chromatographic method development.
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Verified bibliography
- The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.current
Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH
Journal of applied physiology (Bethesda, Md. : 1985) · 2010-10-28 · Journal Article
- Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing.current
Gwyer D, Wragg NM, Wilson SL
Cell and tissue research · 2019-03-27 · Review
- Stable Gastric Pentadecapeptide BPC 157 and Wound Healing.current
Seiwerth S, Milavic M, Vukojevic J, Gojkovic S, Krezic I, Vuletic LB, Pavlov KH, Petrovic A, Sikiric S, Vranes H, Prtoric A, Zizek H, Durasin T, Dobric I, Staresinic M, Strbe S, Knezevic M, Sola M, Kokot A, Sever M, Lovric E, Skrtic A, Blagaic AB, Sikiric P
Frontiers in pharmacology · 2021-06-29 · Review
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Methodology & citation verification
Reference identity is checked against official PubMed metadata. Local deterministic receipts bind each normalized title and canonical metadata record to its verification date. Scientific values remain absent when an authoritative source has not been verified.
Read the full methodology →