Compound monograph
BPC-157
BPC-157 is a synthetic fifteen-residue peptide corresponding to a partial sequence of body protection compound, a protein reported to have been isolated from human gastric juice.
01
Identity & nomenclature
BPC-157 is a synthetic fifteen-residue peptide corresponding to a partial sequence of body protection compound, a protein reported to have been isolated from human gastric juice.
BPC-157 is described in the literature as a partial sequence of body protection compound, a protein reported to have been isolated from human gastric juice. PubChem lists Bepecin and BPC 15 as synonyms. It has no approved regulatory status in any jurisdiction.
Declared aliases and development codes: Bepecin, BPC 15.
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Molecular properties
| Molecular formula | C62H98N16O22 |
|---|---|
| Molecular mass | 1419.5 Da |
| CAS Registry Number | 137525-51-0 |
| PubChem CID | 9941957 |
| UNII | 8ED8NXK95P |
| One-letter sequence | GEPPPGKPADDAGLV |
| Three-letter sequence | Gly–Glu–Pro–Pro–Pro–Gly–Lys–Pro–Ala–Asp–Asp–Ala–Gly–Leu–Val |
| Terminal groups | Free N-terminus; Free C-terminal carboxyl |
Sequence derived from the systematic name in the PubChem molecular record.
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Structural characteristics
The peptide contains three consecutive proline residues at positions 3 to 5 and a fourth proline at position 8. It carries no reported terminal modification in the PubChem molecular record.
Terminal features: Free N-terminus, Free C-terminal carboxyl.
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Molecular targets & mechanisms
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Analytical considerations
The sequence contains no aromatic residues, so UV detection at 280 nm gives no useful chromophore response. Identity confirmation therefore relies on mass and sequence-level methods rather than UV absorbance, and the proline-rich backbone should be accounted for in chromatographic method development.
What the studies reported
Each finding describes one cited study in its stated model. These observations are specific to that study and do not establish effects in other settings.
Cell and tissue studies
Rat Achilles tendon explants
Chang et al. observed significantly accelerated fibroblast outgrowth from rat Achilles tendon explants cultured with BPC 157 in vitro.
Reference [1]Rat Achilles tendon fibroblasts
Chang et al. found no direct effect of BPC 157 on proliferation of cultured rat Achilles tendon fibroblasts in an MTT assay.
Reference [1]Rat Achilles tendon fibroblasts under hydrogen-peroxide stress
Chang et al. observed significantly increased survival of cultured rat Achilles tendon fibroblasts exposed to BPC 157 under hydrogen-peroxide stress.
Reference [1]Rat Achilles tendon fibroblasts
Chang et al. observed increased migration of cultured rat Achilles tendon fibroblasts exposed to BPC 157 in a transwell filter migration assay.
Reference [1]Rat Achilles tendon fibroblasts
Chang et al. observed increased FAK and paxillin phosphorylation with unchanged total protein amounts in cultured rat Achilles tendon fibroblasts exposed to BPC 157.
Reference [1]
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Verified bibliography
Cited studies by type
The 3 papers this record cites, counted by the kind of work each reports. A count is the size of this record's selection, not of the research that exists, and says nothing about results, safety, effectiveness or approval.
A paper can report more than one kind of work. Each count opens those papers in the bibliography. Compare every record on the Evidence Map.
Reference 1
The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH
Journal of applied physiology (Bethesda, Md. : 1985) · 2010-10-28 · Journal Article
currentReference 2
Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing.Gwyer D, Wragg NM, Wilson SL
Cell and tissue research · 2019-03-27 · Review
currentReference 3
Stable Gastric Pentadecapeptide BPC 157 and Wound Healing.Seiwerth S, Milavic M, Vukojevic J, Gojkovic S, Krezic I, Vuletic LB, Pavlov KH, Petrovic A, Sikiric S, Vranes H, Prtoric A, Zizek H, Durasin T, Dobric I, Staresinic M, Strbe S, Knezevic M, Sola M, Kokot A, Sever M, Lovric E, Skrtic A, Blagaic AB, Sikiric P
Frontiers in pharmacology · 2021-06-29 · Review
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Chang CH et al. 2010 | Study models reported: in vitro · from the abstract |
| Gwyer D et al. 2019 | Review article |
| Seiwerth S et al. 2021 | Review article |
Record history
Published 2026-09-04.
- : Sequence and structure
Each entry names the parts of this record that changed on that date. Changes to links between records and to catalogue links are not listed. This history covers the tracked record fields; study findings are not listed here.
Cite this record: Purely Peptides Research Library. BPC-157. Published 2026-09-04; updated 2026-10-14. https://purelypeptides.org/research/compounds/bpc-157/
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Methodology & citation verification
Reference identity is checked against official PubMed metadata. Local deterministic receipts bind each normalized title and canonical metadata record to its verification date. Scientific values remain absent when an authoritative source has not been verified.
Read the full methodology →