Compound monograph
Desmopressin
Desmopressin is a synthetic cyclic peptide construction containing eight amino-acid units and an N-terminal 3-mercaptopropanoyl unit. Its conventional numbering spans nine positions. This record describes the anhydrous parent without acetate or water of crystallization.
01
Identity & nomenclature
Desmopressin is a synthetic cyclic peptide construction containing eight amino-acid units and an N-terminal 3-mercaptopropanoyl unit. Its conventional numbering spans nine positions. This record describes the anhydrous parent without acetate or water of crystallization.
The abbreviation dDAVP identifies the D-Arg8 compound in the structural literature. The abbreviation dAVP is also used for its L-Arg8 counterpart and is not retained as an alias. The position-1 unit is 3-mercaptopropanoyl, rather than cysteine. PubChem CID 5311065 and GSRS UNII ENR1LLB0FP, which lists CAS 16679-58-6, encode the anhydrous parent with D-Arg8, the Mpa1–Cys6 disulfide and Gly9-amide; acetate CAS 62288-83-9 identifies a separate form.
Declared aliases and development codes: dDAVP, 1-deamino-8-D-arginine vasopressin, 1-desamino-8-D-arginine vasopressin.
02
Molecular properties
| CAS Registry Number | 16679-58-6 |
|---|---|
| PubChem CID | 5311065 |
| UNII | ENR1LLB0FP |
| Three-letter sequence | Mpa–Tyr–Phe–Gln–Asn–Cys–Pro–D-Arg–Gly |
| Terminal groups | N-terminal 3-mercaptopropanoyl acyl unit; no free N-terminal alpha-amino group; C-terminal amidation at Gly9 |
Mpa denotes 3-mercaptopropanoyl, an achiral acyl unit at conventional position 1; Tyr is position 2. The C-terminal amide is recorded as a terminal group and is not another residue. Standard one-letter notation cannot specify Mpa1 and D-Arg8 faithfully. The N-terminal acyl chemistry and Mpa1-Cys6 disulfide are outside the automated sequence-formula model.
03
Structural characteristics
Position 1 and glycine at position 9 are achiral. The specified amino-acid stereocentres include D-Arg at position 8. Average molecular mass remains unestablished under the dossier evidence requirements; the molecular formula and mass fields are both withheld.
- Intramolecular disulfide between Mpa1 and L-Cys6
- D-Arg at position 8
Ring closures: covalent bonds between residues, by position counted from the first residue of the chain.
- Disulfide Mpa1–Cys6: thiol sulfur to thiol sulfur (Sγ). Registry source: FDA GSRS UNII ENR1LLB0FP; PubChem CID 5311065.
Terminal features: N-terminal 3-mercaptopropanoyl acyl unit; no free N-terminal alpha-amino group, C-terminal amidation at Gly9.
04
Molecular targets & mechanisms
05
Analytical considerations
Elemental composition and mass alone cannot distinguish this molecule from its L-Arg8 counterpart. The cited NMR characterization does not certify the identity or stereochemical purity of an untested sample.
Disagreements and mix-ups
Points where sources disagree about this compound's identity, or where a name or form is easily confused with another, as noted in this record. The discrepancy register quotes the passage for each one.
Often mixed up · Name or substance
dAVP vs dDAVP
What the studies reported
No verified findings are published for this record under Content Policy v1.
06
Verified bibliography
Cited studies by type
The one paper this record cites, counted by the kind of work each reports. A count is the size of this record's selection, not of the research that exists, and says nothing about results, safety, effectiveness or approval.
A paper can report more than one kind of work. Each count opens those papers in the bibliography. Compare every record on the Evidence Map.
Reference 1
Conformation of desmopressin, an analogue of the peptide hormone vasopressin, in aqueous solution as determined by NMR spectroscopy.Walse B, Kihlberg J, Drakenberg T
European journal of biochemistry · 1998-03-15 · Journal Article
current
Study models of these references
What kind of experiment each cited paper reports, taken from its abstract unless marked. Not a summary of results.
| Reference | Study models |
|---|---|
| Walse B et al. 1998 | Chemical, structural or analytical study; no biological model reported |
Record history
Published 2026-09-28.
- : Sequence and structure
- : Identity and nomenclature
- : Sequence and structure
Each entry names the parts of this record that changed on that date. Changes to links between records and to catalogue links are not listed. This history covers the tracked record fields; study findings are not listed here.
Cite this record: Purely Peptides Research Library. Desmopressin. Published 2026-09-28; updated 2026-10-15. https://purelypeptides.org/research/compounds/desmopressin/
10
Methodology & citation verification
Reference identity is checked against official PubMed metadata. Local deterministic receipts bind each normalized title and canonical metadata record to its verification date. Scientific values remain absent when an authoritative source has not been verified.
Read the full methodology →