Compound monograph
Oxytocin
Oxytocin is a mature nine-residue peptide with an intramolecular disulfide and a terminal carboxamide. This identity record is scoped to the Leu8 form.
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Identity & nomenclature
Oxytocin is a mature nine-residue peptide with an intramolecular disulfide and a terminal carboxamide. This identity record is scoped to the Leu8 form.
OXT and OT are ambiguous abbreviations and are not retained as aliases. The name does not establish the identity of every species variant or commercial preparation.
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Molecular properties
Molecular formula, mass, sequence and registry identifiers are not listed for this record. The sources reviewed did not meet the two-source verification standard used in this library.
Numbering begins at the mature N-terminal residue. The complete sequence is withheld because the source descriptions disagree at residue 4; complete stereochemical admission also remains unresolved.
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Structural characteristics
The disulfide links mature positions 1 and 6, and the C-terminal glycine is amidated. The Gln4 versus glutamyl4 source disagreement leaves the complete sequence, molecular formula and average molecular mass unresolved; those fields are withheld.
- Cys1-Cys6 intramolecular disulfide
Terminal features: Free N-terminus, C-terminal amidation at Gly9.
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Molecular targets & mechanisms
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Analytical considerations
The mature amide, glycine-extended forms and counterion-containing preparations are distinct molecular states. Elemental composition alone does not establish sequence order or complete stereochemistry.
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Verified bibliography
- Oxytocin solution structure changes upon protonation of the N-terminus in dimethyl sulfoxide.
Kato T, Endo S, Fujiwara T, Nagayama K
Journal of biomolecular NMR · 1993-11 · Journal Article
current
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Methodology & citation verification
Reference identity is checked against official PubMed metadata. Local deterministic receipts bind each normalized title and canonical metadata record to its verification date. Scientific values remain absent when an authoritative source has not been verified.
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