Kisspeptin-10 10mg
Kisspeptin-10 (KP-10, metastin 45-54) is the C-terminal decapeptide, Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂, shared by the longer kisspeptins encoded by the KISS1 gene, and carries the RF-amide C-terminus common to the family. This listing contains 10mg of lyophilized material. Supplied strictly for in-vitro research and laboratory use only. Not for human or animal use.
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- Plain, secure packaging
- Certificates published per tested lot — see current coverage
Mechanism of Action
In 2001, two groups identified KiSS-1 gene products as ligands of the orphan G-protein-coupled receptor GPR54 (KISS1R). Ohtaki et al. isolated the 54-residue, C-terminally amidated peptide metastin from human placenta as the endogenous ligand of the receptor. Kotani et al. isolated 54-, 14- and 13-residue kisspeptins with a common RF-amide C-terminus, which bound rat and human GPR54 with low-nanomolar affinity and stimulated PIP₂ hydrolysis, Ca²⁺ mobilization and ERK1/2 and p38 phosphorylation in transfected CHO-K1 cells. Kisspeptin-10 corresponds to the C-terminal ten residues common to these forms.
Properties
CAS Number
374675-21-5
Molecular Formula
C₆₃H₈₃N₁₇O₁₄
Molecular Weight
1302.4 Da
Sequence
Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
Storage
Store lyophilized at -20°C. Reconstituted at 2-8°C, use within 14 days.
Shipping & Delivery
- Same-day dispatch on orders placed before 2 PM MST (Arizona — no daylight saving).
- US shipping from $5. Free Priority on orders $100+ (before discounts).
- Plain, unmarked packaging — no branding or product names on the outside.
- Ships to all 50 states, DC, Puerto Rico & the U.S. Virgin Islands; tracking emailed on every order.
Quality & Testing
- No third-party certificate has been published for this compound yet.
- USA-based; dispatched from Phoenix, Arizona.
- Supplied strictly for in-vitro laboratory research — not for human use.
Certificates are published for each lot we have tested — see the 14 published so far.
Research Applications
References & Citations
(2)Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.
Ohtaki T, Shintani Y, Honda S, et al.
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
Kotani M, Detheux M, Vandenbogaerde A, et al.
Research Use Only
This product is intended strictly for in-vitro research, educational, and laboratory use. Not for human consumption. The information provided is based on published research and does not constitute medical advice.