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Compound Relationship Map

Which peptides in the Research Library are analogues of, contained in, or other forms of each other, and which share a precursor, gene region or peptide family, each quoted from the compound record that states it.

35 stated relationships and 7 shared origins, across 13 families of records.

The map shows only what a compound record says in its own text, and quotes it. The build checks that every quotation still appears, word for word, in that record. Records can be related in other ways: each monograph lists its related compounds, and shared receptors are on the receptor map. Nothing here describes what any compound does.

Analogue of
A synthetic peptide the record describes as built on the parent's sequence.
Sequence contained in
Its residues appear within the longer chain; terminal groups can differ.
Same chain, other form of
Same residues with a different terminal group, acyl group or metal complex.
Shared origin
Records that each state the same precursor protein, gene region, gene family or peptide family.

Amylin (human IAPP)

Open the Amylin (human IAPP) record

  • Analogue of Amylin (human IAPP)

    Cagrilintide
    Cagrilintide is a long-acting synthetic amylin analog…
    Cagrilintide, identity overview

  • Analogue of Amylin (human IAPP)

    Pramlintide
    Pramlintide is an engineered analog of human amylin carrying three proline substitutions…
    Pramlintide, identity overview

Cosyntropin (ACTH 1-24)

Open the Cosyntropin (ACTH 1-24) record

  • Sequence contained in Cosyntropin (ACTH 1-24)

    alpha-MSH
    Note the first thirteen residues are shared with alpha-MSH — the terminal processing is what differs.
    Cosyntropin (ACTH 1-24), sequence notes

    • Sequence contained in alpha-MSH

      KPV
      KPV is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone, residues 11 to 13…
      KPV, nomenclature notes

    • Analogue of alpha-MSH

      Melanotan I (Afamelanotide)
      Afamelanotide, widely supplied as Melanotan I, is a linear thirteen-residue analog of alpha-melanocyte-stimulating hormone carrying norleucine and D-phenylalanine substitutions.
      Melanotan I (Afamelanotide), identity overview

      • Sequence contained in Melanotan I (Afamelanotide)

        KPV
        The same three residues occupy positions 11 to 13 of Melanotan I, where Lys11 follows Gly10 and Val13 carries the C-terminal amide; that containment does not fix the termini of isolated KPV.
        KPV, sequence notes

    • Analogue of alpha-MSH

      Melanotan II
      Melanotan II is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone…
      Melanotan II, identity overview

      • Same chain, other form of Melanotan II

        PT-141 (Bremelanotide)
        The compound is structurally the C-terminal free acid of the Melanotan II scaffold…
        PT-141 (Bremelanotide), nomenclature notes

      • Analogue of Melanotan II

        SHU9119
        SHU9119 shares the Melanotan II ring architecture and differs by a single substitution, D-Phe to D-2-Nal…
        SHU9119, nomenclature notes

    • Analogue of alpha-MSH

      Setmelanotide
      A review by Swan et al. (PMID 38834138) describes setmelanotide as an analogue of alpha-melanocyte-stimulating hormone; that is a review-level parent attribution, not a residue-by-residue design account.
      Setmelanotide, identity overview

    • Analogue of alpha-MSH

      SHU9119
      Gimenez et al. (PMID 35404053) describe SHU9119 as a cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone.
      SHU9119, identity overview

Exenatide · GIP(1-42) · GLP-1(7-37) · Human GLP-2(1-33) · Oxyntomodulin

GIP(1-42)

  • Analogue of GIP(1-42)

    Retatrutide
    …retatrutide is built on a GIP scaffold rather than a GLP-1 scaffold…
    Retatrutide, structural notes

  • Analogue of GIP(1-42)

    Tirzepatide
    The scaffold is GIP, not GLP-1.
    Tirzepatide, structural notes
GLP-1(7-37)

  • Sequence contained in GLP-1(7-37)

    GLP-1(7-36) amide
    GLP-1(7-37) is a separate molecule with an additional terminal glycine and a free carboxyl…
    GLP-1(7-36) amide, nomenclature notes

  • Analogue of GLP-1(7-37)

    Liraglutide
    Built on the GLP-1(7-37) scaffold by a different strategy from semaglutide.
    Liraglutide, structural notes

  • Analogue of GLP-1(7-37)

    Semaglutide
    Built on the GLP-1(7-37) scaffold, retaining its C-terminal glycine.
    Semaglutide, structural notes
Oxyntomodulin

  • Sequence contained in Oxyntomodulin

    Glucagon
    The first twenty-nine are the complete glucagon sequence; the C-terminal extension is KRNRNNIA.
    Oxyntomodulin, sequence notes

  • Analogue of Oxyntomodulin

    Mazdutide
    Described in its literature as an oxyntomodulin analog.
    Mazdutide, structural notes

Shared origin · Same precursor protein

Proglucagon

  • Glucagon
    Glucagon, GLP-1 and oxyntomodulin are related through processing of a shared precursor…
    Glucagon, nomenclature notes
  • Oxyntomodulin
    Oxyntomodulin is an endogenous proglucagon-derived peptide…
    Oxyntomodulin, identity overview
  • GLP-1(7-36) amide
    Deacon et al. (PMID 7556682) isolated this form from human colon and conclude that it is a product of proglucagon processing.
    GLP-1(7-36) amide, identity overview
  • GLP-1(7-37)
    Mojsov et al. (PMID 3543057) describe the glucagon-like peptides as liberated from proglucagon in both the pancreas and the intestine.
    GLP-1(7-37), identity overview
  • Human GLP-2(1-33)
    Orskov et al. (PMID 2714431) characterize human and pig intestinal GLP-2 as a proglucagon processing product.
    Human GLP-2(1-33), identity overview

Shared origin · Same peptide family

Glucagon family

  • GIP(1-42)
    Horváth et al. (PMID 37528104) place GIP among the gastrointestinal peptides of the glucagon family.
    GIP(1-42), identity overview
  • Glucagon
    Horváth et al. (PMID 37528104) place glucagon among the gastrointestinal peptides of the glucagon family.
    Glucagon, identity overview
  • GLP-1(7-36) amide
    Horváth et al. (PMID 37528104) place GLP-1 among the gastrointestinal peptides of the glucagon family.
    GLP-1(7-36) amide, identity overview
  • GLP-1(7-37)
    Horváth et al. (PMID 37528104) place GLP-1 among the gastrointestinal peptides of the glucagon family.
    GLP-1(7-37), identity overview
  • Human GLP-2(1-33)
    Horváth et al. (PMID 37528104) place GLP-2 among the gastrointestinal peptides of the glucagon family.
    Human GLP-2(1-33), identity overview
  • Exenatide
    Horváth et al. (PMID 37528104) place the exendins among the gastrointestinal peptides of the glucagon family.
    Exenatide, identity overview
  • Oxyntomodulin
    A review by Bataille and Dalle (PMID 25115338) describes oxyntomodulin as a member of the glucagon family; that is a review-level family attribution.
    Oxyntomodulin, identity overview

Galanin (human 1-30) · Kisspeptin-14 · Spexin

Kisspeptin-14

  • Sequence contained in Kisspeptin-14

    Kisspeptin-10
    KP-14 contains the kisspeptin-10 sequence at its C terminus.
    Kisspeptin-14, nomenclature notes

Shared origin · Same precursor protein

KISS1-derived peptides

Shared origin · Related genes

Spexin, galanin and kisspeptin genes

GHK (Prezatide)

Open the GHK (Prezatide) record

GHRP-6

Open the GHRP-6 record

Humanin (HN) · SHLP2 · SHLP3 · SHLP6

Humanin (HN)

  • Analogue of Humanin (HN)

    HNG ([Gly14]-Humanin)
    HNG is a synthetic single-substitution analog of humanin carrying glycine in place of serine at position 14.
    HNG ([Gly14]-Humanin), identity overview

  • Analogue of Humanin (HN)

    HNGF6A
    HNGF6A is a synthetic humanin analog with F6A and S14G substitutions…
    HNGF6A, identity overview

Shared origin · Same gene region

Mitochondrial 16S rRNA gene region

  • Humanin (HN)
    Humanin is a 24-residue peptide encoded within the mitochondrial 16S ribosomal RNA gene…
    Humanin (HN), identity overview
  • SHLP2
    SHLP2 is a 26-residue peptide assigned to a small open reading frame within the mitochondrial 16S rRNA region.
    SHLP2, identity overview
  • SHLP3
    SHLP3 is a 38-residue peptide from the same mitochondrial region as humanin…
    SHLP3, identity overview
  • SHLP6
    SHLP6 is a 20-residue peptide assigned to the mitochondrial 16S rRNA region…
    SHLP6, identity overview

KTTKS (Pentapeptide-4)

Open the KTTKS (Pentapeptide-4) record

  • Same chain, other form of KTTKS (Pentapeptide-4)

    Matrixyl
    Palmitoyl pentapeptide-4 is the pentapeptide KTTKS with an N-terminal palmitoyl group…
    Matrixyl, identity overview

Shared origin · Same precursor protein

Type I procollagen

Selank

Open the Selank record

  • Same chain, other form of Selank

    N-Acetyl Selank Amidate
    N-Acetyl Selank Amidate is the Selank heptapeptide with an acetyl group on the N-terminal threonine residue and an amide at the C-terminal proline.
    N-Acetyl Selank Amidate, identity overview

Semax

Open the Semax record

  • Same chain, other form of Semax

    N-Acetyl Semax Amidate
    N-Acetyl Semax Amidate is the Semax heptapeptide with an acetyl group on the N-terminal methionine residue and an amide at the C-terminal proline.
    N-Acetyl Semax Amidate, identity overview

Spadin

Open the Spadin record

  • Sequence contained in Spadin

    PE 22-28
    …the same seven residues form the C-terminal end of the longer sortilin-propeptide-derived peptide spadin…
    PE 22-28, nomenclature notes

Shared origin · Same precursor protein

Sortilin propeptide

  • PE 22-28
    PE 22-28 is a synthetic heptapeptide corresponding to residues 22 to 28 of the sortilin propeptide.
    PE 22-28, identity overview
  • Spadin
    Spadin derives from the propeptide released during sortilin maturation.
    Spadin, nomenclature notes

Tesamorelin

Open the Tesamorelin record

  • Sequence contained in Tesamorelin

    Sermorelin
    Sermorelin, also in this library, is the first 29 residues of this same sequence…
    Tesamorelin, sequence notes

    • Analogue of Sermorelin

      CJC-1295
      CJC-1295 is a tetrasubstituted analog of this fragment…
      Sermorelin, nomenclature notes

Thymosin beta-4

Open the Thymosin beta-4 record

  • Sequence contained in Thymosin beta-4

    Ac-SDKP (Goralatide)
    Ac-SDKP is the acetylated N-terminal tetrapeptide of thymosin beta-4…
    Ac-SDKP (Goralatide), identity overview

  • Sequence contained in Thymosin beta-4

    TB-500
    The residue sequence LKKTETQ corresponds to positions 17-23 of mature human thymosin beta-4…
    TB-500, sequence notes